p53: Guardian of pancreatic epithelial identity.
作者信息
Ghosh Bidyut, Leach Steven D
出版信息
Cell Cycle. 2011 Jun 1;10(11):1717. doi: 10.4161/cc.10.11.15686.
Abstract
摘要
相似文献
1
p53: Guardian of pancreatic epithelial identity.p53：胰腺上皮特性的守护者。
Cell Cycle. 2011 Jun 1;10(11):1717. doi: 10.4161/cc.10.11.15686.
2
Under stress: p53 controls EMT and stemness in pancreatic epithelial cells.
Cell Cycle. 2011 Jun 1;10(11):1715. doi: 10.4161/cc.10.11.15645.
3
Inhibition of epithelial-to-mesenchimal transition: a novel tumor suppressor function of p53?
Cell Cycle. 2011 Aug 15;10(16):2616-7. doi: 10.4161/cc.10.16.16543.
4
p53-dependent regulation of growth, epithelial-mesenchymal transition and stemness in normal pancreatic epithelial cells.p53 依赖性调控正常胰腺上皮细胞的生长、上皮-间充质转化和干性。
Cell Cycle. 2011 Apr 15;10(8):1312-21. doi: 10.4161/cc.10.8.15363.
5
Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.尼古丁通过 Gata6 依赖性去分化胰腺腺泡细胞促进 KRAS 诱导的胰腺癌的发生和进展。
Gastroenterology. 2014 Nov;147(5):1119-33.e4. doi: 10.1053/j.gastro.2014.08.002. Epub 2014 Aug 12.
6
p53 directly activates cystatin D/CST5 to mediate mesenchymal-epithelial transition: a possible link to tumor suppression by vitamin D3.p53直接激活胱抑素D/CST5以介导间充质-上皮转化：这可能是维生素D3发挥肿瘤抑制作用的一个环节。
Oncotarget. 2015 Jun 30;6(18):15842-56. doi: 10.18632/oncotarget.4683.
7
p53 Attenuates the oncogenic Ras-induced epithelial-mesenchymal transition in human mammary epithelial cells.p53 抑制人乳腺上皮细胞中致癌性 Ras 诱导的上皮-间充质转化。
Biochem Biophys Res Commun. 2013 May 10;434(3):606-13. doi: 10.1016/j.bbrc.2013.03.124. Epub 2013 Apr 10.
8
Downregulation of p53 promotes in vitro perineural invasive activity of human salivary adenoid cystic carcinoma cells through epithelial-mesenchymal transition-like changes.p53的下调通过上皮-间质转化样变化促进人涎腺腺样囊性癌细胞的体外神经侵袭活性。
Oncol Rep. 2015 Apr;33(4):1650-6. doi: 10.3892/or.2015.3750. Epub 2015 Jan 26.
9
Ductal adenocarcinoma of the pancreas usually retained SMAD4 and p53 protein status as well as expression of epithelial-to-mesenchymal transition markers and cell cycle regulators at the stage of liver metastasis.胰腺导管腺癌在肝转移阶段通常保留SMAD4和p53蛋白状态以及上皮-间质转化标志物和细胞周期调节因子的表达。
Pol J Pathol. 2014 Jun;65(2):100-12. doi: 10.5114/pjp.2014.43959.
10
p53 counteracts reprogramming by inhibiting mesenchymal-to-epithelial transition.p53 通过抑制间充质-上皮转化来拮抗重编程。
Cell Death Differ. 2013 Feb;20(2):312-20. doi: 10.1038/cdd.2012.125. Epub 2012 Sep 21.
引用本文的文献
1
Mutations of p53 associated with pancreatic cancer and therapeutic implications.与胰腺癌相关的p53突变及其治疗意义
Ann Hepatobiliary Pancreat Surg. 2021 Aug 31;25(3):315-327. doi: 10.14701/ahbps.2021.25.3.315.
2
Zebrafish reporter lines reveal in vivo signaling pathway activities involved in pancreatic cancer.斑马鱼报告基因系揭示了参与胰腺癌的体内信号通路活性。
Dis Model Mech. 2014 Jul;7(7):883-94. doi: 10.1242/dmm.014969. Epub 2014 May 30.
本文引用的文献
1
E2F1 promotes the recruitment of DNA repair factors to sites of DNA double-strand breaks.E2F1 促进 DNA 修复因子向 DNA 双链断裂位点的募集。
Cell Cycle. 2011 Apr 15;10(8):1287-94. doi: 10.4161/cc.10.8.15341.
2
p53-dependent regulation of growth, epithelial-mesenchymal transition and stemness in normal pancreatic epithelial cells.p53 依赖性调控正常胰腺上皮细胞的生长、上皮-间充质转化和干性。
Cell Cycle. 2011 Apr 15;10(8):1312-21. doi: 10.4161/cc.10.8.15363.
3
A minimally invasive assay for individual assessment of the ATM/CHEK2/p53 pathway activity.一种用于个体评估 ATM/CHEK2/p53 通路活性的微创检测方法。
Cell Cycle. 2011 Apr 1;10(7):1152-61. doi: 10.4161/cc.10.7.15231.
4
p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs.p53 通过调节 miRNA 调控上皮-间充质转化和干细胞特性。
Nat Cell Biol. 2011 Mar;13(3):317-23. doi: 10.1038/ncb2173. Epub 2011 Feb 20.
5
Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis.成年胰腺腺泡细胞去分化为具有胚胎祖细胞表型的细胞，并伴随衰老程序的激活，该衰老程序存在于慢性胰腺炎中。
Gut. 2011 Jul;60(7):958-66. doi: 10.1136/gut.2010.225920. Epub 2010 Dec 30.
6
GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage.GCN5 和 E2F1 通过促进损伤部位 H3K9 的乙酰化来刺激核苷酸切除修复。
Nucleic Acids Res. 2011 Mar;39(4):1390-7. doi: 10.1093/nar/gkq983. Epub 2010 Oct 23.
7
p53: guardian of reprogramming.p53：重编程的守护者。
Cell Cycle. 2010 Oct 1;9(19):3887-91. doi: 10.4161/cc.9.19.13301. Epub 2010 Oct 9.
8
The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer?ZEB/miR-200 反馈回路——发育和癌症中细胞可塑性的动力？
EMBO Rep. 2010 Sep;11(9):670-7. doi: 10.1038/embor.2010.117. Epub 2010 Aug 13.
9
E2F1 localizes to sites of UV-induced DNA damage to enhance nucleotide excision repair.E2F1 定位于 UV 诱导的 DNA 损伤部位，以增强核苷酸切除修复。
J Biol Chem. 2010 Jun 18;285(25):19308-15. doi: 10.1074/jbc.M110.121939. Epub 2010 Apr 22.
10
Epithelial-mesenchymal transitions in development and disease.发育与疾病中的上皮-间质转化
Cell. 2009 Nov 25;139(5):871-90. doi: 10.1016/j.cell.2009.11.007.
Zotero 插件