Thiery Jean Paul, Acloque Hervé, Huang Ruby Y J, Nieto M Angela
IMCB, A*STAR, Proteos, Singapore 138673, Republic of Singapore.
Cell. 2009 Nov 25;139(5):871-90. doi: 10.1016/j.cell.2009.11.007.
The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the body plan and in the differentiation of multiple tissues and organs. EMT also contributes to tissue repair, but it can adversely cause organ fibrosis and promote carcinoma progression through a variety of mechanisms. EMT endows cells with migratory and invasive properties, induces stem cell properties, prevents apoptosis and senescence, and contributes to immunosuppression. Thus, the mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
上皮-间质转化（EMT）在机体形态形成以及多种组织和器官的分化过程中发挥着关键作用。EMT 也有助于组织修复，但它可能通过多种机制对器官纤维化产生不利影响并促进癌症进展。EMT 赋予细胞迁移和侵袭特性，诱导干细胞特性，防止细胞凋亡和衰老，并有助于免疫抑制。因此，间充质状态与细胞迁移至远处器官并维持干性的能力相关，从而使其在发育过程中能够随后分化为多种细胞类型并启动转移。
