Arnault F, Maitre P, Cachon T, Carozzo C, Fau D, Genevois J-P, Viguier E
CHEVAC, VetAgro Sup, Campus Vétérinaire de Lyon / ENSV, , 1 avenue Bourgelat, 69280 Marcy L'Etoile, France.
Vet Comp Orthop Traumatol. 2011;24(4):289-93. doi: 10.3415/VCOT-10-11-0155. Epub 2011 May 20.
To report the successful use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in the treatment of an antebrachial non-union, secondary to gunshot fracture, stabilized with circular external fixation in a cat.
Following a diagnosis of a highly comminuted gunshot fracture of the distal right radius and ulna, the fracture was stabilized with a circular external fixation. A two-ring frame was placed in closed fashion.
The skin wound healed uneventfully by second intention in 21 days. Twenty-eight weeks after external fixation, bone healing was absent. 0.8mL of 0.2mg/mL of rhBMP-2 in two collagen sponges was placed in the bone defect. Eight weeks after rhBMP-2 implantation, an early bone healing response was noted on radiographic evaluation. Sixteen weeks after rhBMP-2 implantation, fracture union was achieved.
To the authors' knowledge, 160 μg is the lowest reported dose of rhBMP-2 that leads to bony union in a cat. However as an individual case study, this report can not be used as evidence that rhBMP-2 at this lower dose is appropriate for use in all cats. Further studies are needed to establish the minimum efficient dose of rhBMP-2 in cats.
报告重组人骨形态发生蛋白-2（rhBMP-2）成功用于治疗猫前臂枪伤骨折继发骨不连的病例，该骨折采用环形外固定架固定。
诊断为右桡骨远端和尺骨高度粉碎性枪伤骨折后，用环形外固定架固定骨折。以闭合方式放置双环框架。
皮肤伤口通过二期愈合在21天内顺利愈合。外固定28周后，骨愈合未出现。将0.8mL浓度为0.2mg/mL的rhBMP-2置于两块胶原海绵中，放入骨缺损处。rhBMP-2植入8周后，影像学评估显示出现早期骨愈合反应。rhBMP-2植入16周后，骨折实现愈合。
据作者所知，160μg是报道的rhBMP-2在猫中导致骨愈合的最低剂量。然而，作为一个个案研究，本报告不能用作该较低剂量rhBMP-2适用于所有猫的证据。需要进一步研究以确定rhBMP-2在猫中的最低有效剂量。
