Chung Cheng-Shu, Lin Lee-Shuan, Teo Yi-Min
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan.
Laboratory of Veterinary Diagnostic Imaging, Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan.
Front Vet Sci. 2021 Nov 25;8:756167. doi: 10.3389/fvets.2021.756167. eCollection 2021.
A 5-year-old, intact male Bengal cat weighing 5.2 kg was referred for the fixation failure of a right femoral fracture. Multiple surgical revisions failed, and atrophic non-union was diagnosed. The cat was then admitted for a final revision surgery using locking plate fixation in conjunction with rib and iliac crest autografts and recombinant human bone morphogenetic protein 2 (rhBMP-2). The fracture site was debrided and stabilized before filling the defect with 1.8 cm of rib bone autograft. The residual space in the defect was then filled with an iliac crest autograft. Finally, a 3 ×5 cm absorbable collagen sponge soaked with 0.5 mL of 0.2 mg/mL rhBMP-2 solution was placed around the defect. No significant complications were noted postoperatively. Bone healing was noted 2 months postoperatively, and it continued for 12 months. Although mild lameness remained, the cat's ambulatory function and quality of life were good. To the authors' knowledge, this is the first case report of a clinical transplantation of a rib segment as an autograft in combination with rhBMP-2 in a cat with a large bone defect.
一只5岁、未绝育的雄性孟加拉猫，体重5.2千克，因右股骨骨折内固定失败前来就诊。多次手术翻修均失败，诊断为萎缩性骨不连。随后该猫入院接受最终翻修手术，采用锁定钢板固定，并结合肋骨和髂嵴自体骨移植以及重组人骨形态发生蛋白2（rhBMP-2）。在骨折部位清创并稳定后，先用1.8厘米的肋骨自体骨填充缺损。然后用髂嵴自体骨填充缺损处的剩余空间。最后，将一块浸泡在0.5毫升0.2毫克/毫升rhBMP-2溶液中的3×5厘米可吸收胶原海绵放置在缺损周围。术后未发现明显并发症。术后2个月观察到骨愈合，并持续了12个月。尽管仍有轻度跛行，但该猫的行走功能和生活质量良好。据作者所知，这是首例在患有大骨缺损的猫中，将肋骨段作为自体骨与rhBMP-2联合进行临床移植的病例报告。
