S CROCE GEN HOSP,CLIN PATHOL LAB,I-12100 CUNEO,ITALY.
Oncol Rep. 1995 Jul;2(4):637-41. doi: 10.3892/or.2.4.637.
In this prospective study we aimed at assessing the potential prognostic significance of the serum protein content. We studied 388 consecutive patients, newly diagnosed for lung cancer during the last 6 years, by measuring the serum concentration of immunoglobulins (IgG, IgA, IgM), transferrin (T), haptoglobin (HP), alpha-1-acid glycoprotein (AGP), alpha-1-antitrypsin (AT) and alpha-2-macroglobulin (MG). In all patients, the values of other 9 clinical variables (age, sex, weight loss, ECOG performance status, stage- of disease, TNM factors and histology) were also available. Univariate analysis showed that patients with transferrin above 218 mg/dl had a median survival of 9 months, as compared to the 7 months for the remaining subjects (p<0.01). Patients with AT above 281 mg/dl had a significantly shorter survival than patients with low AT (11 months vs 6 months, p<0.01). High AP and AGP were also significantly associated with a poor prognosis (p<0.01 and 0.05 respectively). A multivariate analysis of survival (the Cox's proportional hazards regression analysis), selected, in decreasing order of significance, the following variables: (i) stage of disease; (ii) ECOG performance status; (iii) sex; (iv) alpha-1-acid glycoprotein; (v) weight loss; (vi) histology. We conclude that serum proteins (particularly AGP, T and AT) do have some prognostic significance in lung cancer.
在这项前瞻性研究中，我们旨在评估血清蛋白含量的潜在预后意义。我们通过测量免疫球蛋白（IgG、IgA、IgM）、转铁蛋白（T）、触珠蛋白（HP）、α-1-酸性糖蛋白（AGP）、α-1-抗胰蛋白酶（AT）和α-2-巨球蛋白（MG）的血清浓度，研究了过去 6 年期间新诊断为肺癌的 388 例连续患者。在所有患者中，还可获得其他 9 个临床变量（年龄、性别、体重减轻、ECOG 表现状态、疾病分期、TNM 因素和组织学）的值。单因素分析显示，转铁蛋白水平高于 218mg/dl 的患者中位生存期为 9 个月，而其余患者为 7 个月（p<0.01）。AT 水平高于 281mg/dl 的患者的生存期明显短于 AT 水平低的患者（11 个月比 6 个月，p<0.01）。高 AGP 和 AP 也与预后不良显著相关（p<0.01 和 0.05）。生存的多因素分析（Cox 比例风险回归分析）按意义降序选择了以下变量：（i）疾病分期；（ii）ECOG 表现状态；（iii）性别；（iv）α-1-酸性糖蛋白；（v）体重减轻；（vi）组织学。我们得出结论，血清蛋白（特别是 AGP、T 和 AT）在肺癌中确实具有一定的预后意义。
