Hayashi T, Hayashi K, Uchida K, Niwayama S, Morita N
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Chem Pharm Bull (Tokyo). 1990 Jan;38(1):239-42. doi: 10.1248/cpb.38.239.
Scopadulcic acid B derivatives were synthesized and their antiviral activities against herpes simplex virus type 1 (HSV-1) were examined. All the derivatives synthesized showed lower inhibitory activities against HSV-1 than scopadulcic acid B (2). Five compounds, 7, 8, 15, 16, and 18, however, had in vitro therapeutic indexes larger than 7 and were considered to merit further investigation.
合成了scopadulcic酸B的衍生物，并检测了它们对单纯疱疹病毒1型（HSV-1）的抗病毒活性。所有合成的衍生物对HSV-1的抑制活性均低于scopadulcic酸B（2）。然而，化合物7、8、15、16和18这五种化合物的体外治疗指数大于7，被认为值得进一步研究。
