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[Biological effects of coordinated compounds of transitional metals. 7. Antiviral activity of 4-methyl-2-aminopyridine palladium chloride against herpes simplex virus type 1 and type 2 in vitro and in vivo].

作者信息

Wutzler P, Thiel K D, Tonew M, Tonew E, Schröer H P, Stelzner A

机构信息

Medizinische Akademie Erfurt, Institut für Medizinische Mikrobiologie, DDR.

出版信息

Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Oct;266(3-4):563-6.

PMID:2830739
Abstract

4-Methyl-2-amino-pyridine-palladium chloride (MAP) showed an antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a serum-free medium under in vitro conditions. The replication of these viruses on primary rabbit testes cells was completely suppressed by 10(-5) M/l MAP. In animal tests using ABD2-mice the course of HSV-1 and HSV-2 encephalitis was not influenced by MAP indicated by mean survival time and lethality.

摘要

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