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[脂多糖和脂多糖结合蛋白血清水平在癌症合并脓毒症患者中的预后价值]

[Prognostic value of lipopolysaccharide and lipopolysaccharide-binding protein serum levels in cancer patients with sepsis].

作者信息

Anisimova N Iu, Gromova E G, Kuznetsova L S, Kiselevskiĭ M V

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 2011 Mar-Apr(2):82-4.

PMID:21598623
Abstract

AIM

Analysis of LPS and LPS-binding protein (LBP) serum levels and prognostic value evaluation in cancer patients with sepsis.

MATERIALS AND METHODS

Blood samples of 17 healthy donors and 46 cancer patients with sepsis were analyzed by using "Hycult biotechnology" kits (The Netherlands).

RESULTS

Serum LPS level in cancer patients with sepsis was increased significantly. A substantial decrease of LBP level was detected in blood samples of deceased patients.

CONCLUSION

Dynamic increase of LPS serum level and decrease of LPS-binding protein serum level in cancer patients should be considered as an unfavorable factor for sepsis.

摘要

目的

分析脓毒症癌症患者血清中脂多糖（LPS）和脂多糖结合蛋白（LBP）水平并评估其预后价值。

材料与方法

使用荷兰“Hycult生物技术”试剂盒对17名健康供者和46名脓毒症癌症患者的血样进行分析。

结果

脓毒症癌症患者血清LPS水平显著升高。在死亡患者的血样中检测到LBP水平大幅下降。

结论

癌症患者血清LPS水平动态升高和LPS结合蛋白血清水平下降应被视为脓毒症的不利因素。

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