健康受试者高剂量吸入沙美特罗的剂量反应研究。
Dose-response study with high-dose inhaled salmeterol in healthy subjects.
作者信息
Maconochie J G, Forster J K
机构信息
Department of Clinical Pharmacology, Glaxo Group Research Limited, Greenford, Middlesex.
出版信息
Br J Clin Pharmacol. 1992 Mar;33(3):342-5. doi: 10.1111/j.1365-2125.1992.tb04049.x.
Abstract
A double-blind, placebo-controlled, cross-over study in 10 healthy male subjects has been carried out to investigate the non-pulmonary effects of single inhaled doses of salmeterol 100 micrograms, 200 micrograms and 400 micrograms and salbutamol 400 micrograms from a metered-dose inhaler. At all doses tested, salmeterol produced statistically significant changes in pulse rate, tremor, blood glucose and plasma potassium concentrations, compared with placebo. All changes were dosed related. A number of dose-related adverse events including tremor, awareness of heart beat and headache were reported after salmeterol administration.
摘要
在10名健康男性受试者中进行了一项双盲、安慰剂对照的交叉研究，以调查从定量吸入器单次吸入100微克、200微克和400微克沙美特罗以及400微克沙丁胺醇的非肺部效应。在所有测试剂量下，与安慰剂相比，沙美特罗在脉搏率、震颤、血糖和血浆钾浓度方面产生了具有统计学意义的变化。所有变化均与剂量相关。沙美特罗给药后报告了一些与剂量相关的不良事件，包括震颤、心跳感知和头痛。
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