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一种新型水溶性七铂类似物，具有提高的抗肿瘤活性和降低的毒性。

A novel water-soluble heptaplatin analogue with improved antitumor activity and reduced toxicity.

机构信息

State Key Lab of Advanced Technologies for PGMs, Kunming Institute of Precious Metals, Kunming 650106, PR China.

出版信息

Inorg Chem. 2011 Jun 20;50(12):5324-6. doi: 10.1021/ic200436u. Epub 2011 May 20.

DOI:10.1021/ic200436u
PMID:21598993
Abstract

A novel water-soluble heptaplatin analogue, cis-(4R,5R)-4,5-bis-(aminomethyl)-2-isopropyl-1,3-dioxolaneplatinum(II), has been synthesized and biologically evaluated. The complex shows more activity and less toxicity than its parent drug heptaplatin, exhibiting the great potential for further development.

摘要

一种新型水溶性庚铂类似物，顺式-(4R,5R)-4,5-双-(氨甲基)-2-异丙基-1,3-二氧戊环铂(II)，已被合成并进行了生物学评价。该配合物比其母体药物庚铂具有更高的活性和更低的毒性，显示出进一步开发的巨大潜力。

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