Fry M, Vande Zande H, Green D E
Proc Natl Acad Sci U S A. 1978 Dec;75(12):5908-11. doi: 10.1073/pnas.75.12.5908.
Cytochrome c oxidase (ferrocytochrome c: oxygen oxidoreductase, EC 1.9.3.1) has been resolved into a pair of complexes of unequal molecular weight. The larger complex (electron transfer complex) contains exclusively the oxidation-reduction proteins characteristic of cytochrome oxidase; the smaller complex (ion transfer complex) shows exclusively the capability for cation-dependent induction of the fluorescence of 8-anilino-1-naphthalenesulfonic acid--a capability demonstrable in preparations of cytochrome oxidase. The duplex nature of cytochrome oxidase has important implications for the mechanism of energy coupling.
细胞色素c氧化酶（亚铁细胞色素c：氧氧化还原酶，EC 1.9.3.1）已被解析为一对分子量不等的复合物。较大的复合物（电子传递复合物）仅包含细胞色素氧化酶特有的氧化还原蛋白；较小的复合物（离子传递复合物）仅表现出阳离子依赖性诱导8-苯胺基-1-萘磺酸荧光的能力——这种能力在细胞色素氧化酶制剂中可得到证实。细胞色素氧化酶的双重性质对能量偶联机制具有重要意义。
