磷脂作为生物膜中离子和溶质运输的分子工具。
Phospholipids as the molecular instruments of ion and solute transport in biological membranes.
作者信息
Green D E, Fry M, Blondin G A
出版信息
Proc Natl Acad Sci U S A. 1980 Jan;77(1):257-61. doi: 10.1073/pnas.77.1.257.
Abstract
Partition studies have established that phospholipids generally have the capabilities to mediate the transmembrane transport of the full range of ions and solutes that physiologically cross biological membranes. The list of transportable species includes cations, anions, amino acids, citric acid cycle intermediates, nucleotides, and sugars. Phospholipid-mediated transport can be readily modulated by altering the phospholipid mixture or by addition of detergents, nucleotides, divalent metals, proteins, peptides, or ring compounds. Containment of phospholipid within channels in protein appears to be the precondition for the formation of the micellar structure requisite for solute transport. Phospholipid-mediated transport is postulated to be a central feature of energy coupling, membrane-spanning systems, and membrane-bound, phospholipid-requiring enzymes.
摘要
分配研究已证实，磷脂通常能够介导生理条件下跨生物膜的各种离子和溶质的跨膜运输。可运输的物质包括阳离子、阴离子、氨基酸、柠檬酸循环中间体、核苷酸和糖类。通过改变磷脂混合物或添加去污剂、核苷酸、二价金属、蛋白质、肽或环状化合物，可轻易调节磷脂介导的运输。蛋白质通道内磷脂的存在似乎是形成溶质运输所需胶束结构的先决条件。磷脂介导的运输被认为是能量偶联、跨膜系统以及膜结合的、需要磷脂的酶的核心特征。
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