Palefsky J M, Gonzales J, Greenblatt R M, Ahn D K, Hollander H
Department of Laboratory Medicine, University of California-San Francisco 94143.
JAMA. 1990 Jun 6;263(21):2911-6.
Ninety-seven male homosexuals with the acquired immunodeficiency syndrome or other group IV human immunodeficiency virus disease were studied for anal human papillomavirus infection and intra-anal cytological abnormalities. Human papillomavirus DNA was detected in 52 subjects (54%), and 38 subjects (39%) were found to have abnormal anal cytological findings; anal intraepithelial neoplasia was detected in 15 specimens (15%). Abnormalities on anal cytological smear were significantly associated with the presence of human papillomavirus DNA, with a risk ratio of 4.6. Infection with multiple human papillomavirus types was common (12%) and was associated with a risk ratio for cytological abnormalities of 39.0. Median T4 counts of subjects with abnormal cytological findings were significantly lower than those with normal findings. These studies indicate that immunosuppressed male homosexuals have a high prevalence of anal human papillomavirus infection and anal intraepithelial neoplasia, and this population may be at significant risk for the development of anal cancer.
对97名患有获得性免疫缺陷综合征或其他IV组人类免疫缺陷病毒疾病的男性同性恋者进行了肛门人乳头瘤病毒感染及肛门内细胞学异常情况的研究。在52名受试者（54%）中检测到了人乳头瘤病毒DNA，38名受试者（39%）被发现存在肛门细胞学异常；在15份标本（15%）中检测到了肛门上皮内瘤变。肛门细胞学涂片异常与人乳头瘤病毒DNA的存在显著相关，风险比为4.6。多种人乳头瘤病毒类型感染很常见（12%），且与细胞学异常的风险比为39.0相关。细胞学检查结果异常的受试者的T4细胞计数中位数显著低于结果正常的受试者。这些研究表明，免疫抑制的男性同性恋者肛门人乳头瘤病毒感染和肛门上皮内瘤变的患病率很高，且该人群可能面临患肛门癌的重大风险。
