Critchlow C W, Holmes K K, Wood R, Krueger L, Dunphy C, Vernon D A, Daling J R, Kiviat N B
Department of Biostatistics, University of Washington, Seattle 98195.
Arch Intern Med. 1992 Aug;152(8):1673-6.
A previous study of men with proctitis, proctocolitis, or enteritis showed an association of anal human papillomavirus (HPV) infection with human immunodeficiency virus (HIV) infection. Because anorectal abnormalities may confound an observed association between anal HPV DNA and HIV seropositivity, the present study was undertaken among consecutive homosexual men seeking HIV serologic testing who were unselected for anorectal symptoms.
Consecutive homosexual men underwent a standardized interview, physical examination, and collection of specimens for HIV serologic testing and detection of anal HPV DNA.
Anal HPV DNA was detected in eight (31%) of 26 HIV-seropositive men and in 10 (8%) of 119 HIV-seronegative men (odds ratio, 5.8; 95% confidence interval, 1.1 to 30.1, adjusted for history of sexually transmitted disease, current anorectal symptoms, and age). When men with anorectal symptoms were excluded from the analysis, anal HPV DNA was detected in 27% of seropositive men compared with 8% of seronegative men (odds ratio, 4.4; 95% confidence interval, 1.4 to 13.4). There was no difference between HIV-seropositive and HIV-seronegative men with respect to distribution of type of HPV DNA. Men with group II or III and group IV HIV disease were 4.1 and 10.9 times, respectively, more likely than HIV-seronegative men to have anal HPV DNA detected.
Because HIV-seropositive men appear to be at increased risk for the detection of anal HPV DNA, the natural course of anal HPV infection should be compared among HIV-seropositive and HIV-seronegative homosexual men.
先前一项针对患有直肠炎、直肠结肠炎或肠炎男性的研究显示，肛门人乳头瘤病毒（HPV）感染与人类免疫缺陷病毒（HIV）感染之间存在关联。由于肛肠异常可能会混淆所观察到的肛门HPV DNA与HIV血清阳性之间的关联，因此本研究在连续寻求HIV血清学检测且未因肛肠症状而被筛选的同性恋男性中进行。
连续的同性恋男性接受了标准化访谈、体格检查，并采集了用于HIV血清学检测和肛门HPV DNA检测的标本。
在26名HIV血清阳性男性中有8名（31%）检测到肛门HPV DNA，在119名HIV血清阴性男性中有10名（8%）检测到（优势比为5.8；95%置信区间为1.1至30.1，对性传播疾病史、当前肛肠症状和年龄进行了校正）。当将有肛肠症状的男性排除在分析之外时，血清阳性男性中有27%检测到肛门HPV DNA，而血清阴性男性中这一比例为8%（优势比为4.4；95%置信区间为1.4至13.4）。在HIV血清阳性和血清阴性男性之间，HPV DNA类型的分布没有差异。患有II或III组以及IV组HIV疾病的男性检测到肛门HPV DNA的可能性分别是HIV血清阴性男性的4.1倍和10.9倍。
由于HIV血清阳性男性检测到肛门HPV DNA的风险似乎增加，因此应该比较HIV血清阳性和血清阴性同性恋男性中肛门HPV感染的自然病程。
