Merck KGaA, Merck Serono, Portfolio Development, Frankfurterstr. 250, D-64293 Darmstadt, Germany.
Drug Discov Today. 2011 Jul;16(13-14):609-18. doi: 10.1016/j.drudis.2011.04.012. Epub 2011 May 11.
Portfolio management in drug development has become a best practice in the pharmaceutical industry. By contrast, early on in the value chain - the discovery phase - portfolio management is still in its infancy. Nevertheless, owing to the attrition of R&D projects from phase to phase and the cost of capital involved, these early phases of drug discovery play a significant part for the overall cost of bringing new, innovative drugs to the market. This paper describes various approaches to manage a portfolio of projects in early-stage drug discovery and provides crucial factors that determine the success of such an approach.
药物研发中的项目组合管理已成为制药行业的一项最佳实践。相比之下，在价值链的早期——发现阶段——项目组合管理仍处于起步阶段。然而，由于研发项目在各阶段的损耗以及所涉及的资金成本，药物发现的早期阶段对将新型创新药物推向市场的总成本起着重要作用。本文介绍了在药物发现早期阶段管理项目组合的各种方法，并提供了决定此类方法成功的关键因素。
