β2 肾上腺素能受体基因型与足月及晚期早产儿活跃期进展的关系。
Beta-2 adrenoceptor genotype and progress in term and late preterm active labor.
机构信息
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY 10032, USA.
出版信息
Am J Obstet Gynecol. 2011 Aug;205(2):137.e1-7. doi: 10.1016/j.ajog.2011.03.045. Epub 2011 Apr 2.
OBJECTIVE
We sought to evaluate whether beta-2 adrenoceptor (β2AR) genotype at a functional polymorphic site encoding for amino acid residue 16 influences rate of cervical dilatation in term and late preterm active labor.
STUDY DESIGN
Subjects who underwent vaginal delivery at ≥34 weeks' gestational age from May 2006 through August 2007 were identified. Each subject had provided venous blood from which DNA was extracted for β2AR genotyping. Digital cervical examinations with paired examination times were collected from intrapartum records. Rate of cervical dilatation in active labor was determined using linear regression. Rates were compared between genotype groups.
RESULTS
Among 401 subjects with satisfactory genotype and intrapartum data, overall rate of active labor was 0.76±0.01 cm/h. When labor was compared by genotype, homozygous Arg/Arg16 subjects progressed at a slower rate (0.64±0.03 cm/h) than all other pooled genotypes (0.8±0.02 cm/h, P<.001).
CONCLUSION
Homozygous β2AR genotype encoding for Arg/Arg16 was associated with slower progress in active labor.
目的
评估β-2 肾上腺素能受体（β2AR）在编码氨基酸残基 16 的功能多态性位点的基因型是否影响足月和晚期早产活跃分娩时宫颈扩张的速度。
研究设计
我们确定了 2006 年 5 月至 2007 年 8 月期间在≥34 孕周行阴道分娩的受试者。每位受试者均提供了静脉血，从中提取 DNA 进行β2AR 基因分型。从产时记录中收集配对检查时间的数字宫颈检查。使用线性回归确定活跃分娩时宫颈扩张的速度。比较基因型组之间的速度。
结果
在 401 名具有满意基因型和产时数据的受试者中，活跃分娩的总体速度为 0.76±0.01cm/h。按基因型比较分娩时，Arg/Arg16 纯合子的进展速度较慢（0.64±0.03cm/h），明显慢于所有其他聚集基因型（0.8±0.02cm/h，P<.001）。
结论
编码 Arg/Arg16 的β2AR 基因型纯合子与活跃分娩时的进展缓慢有关。
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