Research Group for Carbohydrates of Hungarian Academy of Sciences, University of Debrecen, PO Box 94, H-4010 Debrecen, Hungary.
Carbohydr Res. 2011 Sep 6;346(12):1628-32. doi: 10.1016/j.carres.2011.04.024. Epub 2011 Apr 29.
Simple analogues of lipid II were synthesized from 3,4,6-tri-O-acetyl-2-acetamido-2-deoxy-1-thio-β-D-glucopyranose using conjugate addition onto ethylidene bisphosphonate and subsequent Wadsworth-Horner-Emmons reaction with long chain aliphatic aldehydes.
合成了 3,4,6-三-O-乙酰基-2-乙酰氨基-2-脱氧-1-硫代-β-D-吡喃葡萄糖，并通过与亚乙基双膦酸酯的共轭加成以及随后与长链脂肪醛的 Wadsworth-Horner-Emmons 反应，得到了脂质 II 的简单类似物。
