帕克核苷酸及脂质I和II类似物的固相模块合成
Solid-Phase Modular Synthesis of Park Nucleotide and Lipids I and II Analogues.
作者信息
Katsuyama Akira, Sato Kousuke, Yakushiji Fumika, Matsumaru Takanori, Ichikawa Satoshi
机构信息
Faculty of Pharmaceutical Science, Hokkaido University.
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Kanazawa 1757.
出版信息
Chem Pharm Bull (Tokyo). 2018;66(1):84-95. doi: 10.1248/cpb.c17-00828.
A solid-phase synthesis of Park nucleotide as well as lipids I and II analogues, which is applicable to the synthesis of a range of analogues, is described in this work. This technique allows highly functionalized macromolecules to be modularly labeled. Multiple steps are used in a short time (4 d) with a single purification step to synthesize the molecules by solid-phase synthesis.
本文描述了一种适用于一系列类似物合成的帕克核苷酸以及脂质I和II类似物的固相合成方法。该技术能够对高度官能化的大分子进行模块化标记。通过固相合成，在短时间内（4天）采用多个步骤并经过单一纯化步骤来合成这些分子。
Zotero 插件