Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, United States.
Psychoneuroendocrinology. 2011 Nov;36(10):1520-9. doi: 10.1016/j.psyneuen.2011.04.006. Epub 2011 May 19.
Neurogenesis in the dentate gyrus of the hippocampus of adult laboratory animals has been widely reported to be vulnerable to many psychological and physical stressors. However, we have found no effects of acute restraint stress, acute or subchronic tailshock stress, or acute, subchronic, or chronic resident-intruder stress on neural progenitor cell (NPC) proliferation, short or long term survival of newborn cells, or brain-derived neurotrophic factor (BDNF) mRNA expression in adult rats. In addition, we did not observe any effect of chronic resident-intruder stress on NPC proliferation in adolescent rats. A selectively bred stress-sensitive line was also found to exhibit no alterations in NPC proliferation following tailshock stress, although this line did exhibit a lower proliferation rate under baseline (unstressed) conditions when compared with non-selected rats. These results challenge the prevailing hypothesis that any stressor of sufficient intensity and duration has a marked negative impact upon the rate of hippocampal neurogenesis, and suggest that some yet unidentified factors related to stress and experimental conditions are crucial in the regulation of neurogenesis.
成年实验动物海马齿状回中的神经发生已被广泛报道易受许多心理和生理应激源的影响。然而，我们没有发现急性束缚应激、急性或亚慢性尾部电击应激、急性、亚慢性或慢性群居-入侵应激对成年大鼠神经祖细胞（NPC）增殖、新生细胞的短期或长期存活或脑源性神经营养因子（BDNF）mRNA 表达有任何影响。此外，我们也没有观察到慢性群居-入侵应激对青少年大鼠 NPC 增殖的任何影响。选择性繁殖的应激敏感系也被发现，其在尾部电击应激后 NPC 增殖没有改变，尽管与非选择大鼠相比，该系在基础（无应激）条件下的增殖率较低。这些结果对普遍存在的假设提出了挑战，即任何强度和持续时间足够的应激源都会对海马神经发生的速度产生显著的负面影响，并表明与应激和实验条件有关的一些尚未确定的因素在神经发生的调节中至关重要。
