Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
J Am Coll Cardiol. 2011 May 31;57(22):2284-9. doi: 10.1016/j.jacc.2011.04.003.
This study sought to describe the clinical correlates and heritability of the early repolarization pattern (ERP) in 2 large, population-based cohorts.
There is growing recognition that ERP is associated with adverse outcomes.
Participants of the Framingham Heart Study (FHS) (N = 3,995) and the Health 2000 Survey (H2K) (N = 5,489) were included. ERP was defined as a J-point elevation ≥0.1 mV in ≥2 leads in either the inferior (II, III, aVF) or lateral (I, aVL, V(4-6)) territory or both. We tested the association between clinical characteristics and ERP, and estimated sibling recurrence risk.
ERP was present in 243 of 3,955 (6.1%) of FHS and 180 of 5,489 (3.3%) of H2K subjects. Male sex, younger age, lower systolic blood pressure, higher Sokolow-Lyon index, and lower Cornell voltage were independently associated with the presence of ERP. In the FHS sample, siblings of individuals with ERP had an ERP prevalence of 11.6% (recurrence risk ratio of 1.89). Siblings of individuals with ERP had an increased unadjusted odds of ERP (odds ratio: 2.22, 95% confidence interval: 1.01 to 4.85, p = 0.047).
ERP has strong association with clinical factors and has evidence for a heritable basis in the general population. Further assessment of the genetic determinants of ERP is warranted.
本研究旨在描述 2 个大型人群队列中早期复极（ERP）的临床相关性和遗传性。
越来越多的人认识到 ERP 与不良结局相关。
纳入弗雷明汉心脏研究（FHS）（N=3995）和健康 2000 调查（H2K）（N=5489）的参与者。ERP 定义为在下壁（II、III、aVF）或侧壁（I、aVL、V（4-6））或两者中至少 2 个导联 J 点抬高≥0.1 mV。我们检验了临床特征与 ERP 的相关性，并估计了同胞复发风险。
FHS 中 3955 例（6.1%）和 H2K 中 5489 例（3.3%）存在 ERP。男性、年龄较小、收缩压较低、Sokolow-Lyon 指数较高和 Cornell 电压较低与 ERP 的存在独立相关。在 FHS 样本中，ERP 个体的同胞 ERP 患病率为 11.6%（复发风险比为 1.89）。ERP 个体的同胞在未经调整的 ERP 发生比值比方面具有较高的优势（比值比：2.22，95%置信区间：1.01 至 4.85，p=0.047）。
ERP 与临床因素密切相关，并且在普通人群中具有遗传性基础。进一步评估 ERP 的遗传决定因素是必要的。
