National Research Council Institute for Biodiagnostics (Atlantic), Halifax, Nova Scotia, Canada.
Clin Neurophysiol. 2011 Nov;122(11):2236-45. doi: 10.1016/j.clinph.2011.04.018. Epub 2011 May 19.
To determine whether the classic inverse relationship between the amplitude of the mismatch negativity (MMN) and deviant probability can be demonstrated to violations of a concrete rule pattern.
In Experiment 1, oddball and patterned auditory sequences were presented with high (p = 0.16) and rare (p = 0.02) deviant probability. In Experiment 2, a slightly different pattern was presented with high, moderate (p = 0.08), low (p = 0.04), and rare deviant probability. In Experiment 3, deviants in the patterns from Experiments 1 and 2 were actively detected at high and rare probability.
In Experiment 1, the amplitude of the MMN varied inversely with deviant probability in both conditions. In Experiment 2, no effect of probability was observed. Experiment 3 supported the hypothesis that high deviant probability causes instability in the memory representation of the standard in the pattern from Experiment 1.
The amplitude of the MMN to concrete pattern violations does not vary with deviant probability.
The amplitude of the MMN may not vary with deviant probability. Once a stable memory representation is formed for the standard regularities in an auditory sequence, further examples may not strengthen that representation.
确定经典的失匹配负波（MMN）幅度与偏差概率之间的反比关系是否可以证明违反具体规则模式。
在实验 1 中，以高（p = 0.16）和低（p = 0.02）偏差概率呈现了偶然和模式化的听觉序列。在实验 2 中，以高、中（p = 0.08）、低（p = 0.04）和低偏差概率呈现了略有不同的模式。在实验 3 中，在高和低偏差概率下主动检测了来自实验 1 和 2 的模式中的偏差。
在实验 1 中，在两种情况下，MMN 的幅度都与偏差概率呈反比。在实验 2 中，未观察到概率的影响。实验 3 支持了这样的假设，即高偏差概率导致模式中标准的记忆表示不稳定。
MMN 对具体模式违反的幅度不随偏差概率而变化。
MMN 的幅度可能不随偏差概率而变化。一旦为听觉序列中的标准规则形成了稳定的记忆表示，进一步的例子可能不会增强该表示。
