Czyrak A, Mogilnicka E, Siwanowicz J, Maj J
Polish Academy of Sciences, Institute of Pharmacology, Kraków.
Pharmacol Biochem Behav. 1990 Mar;35(3):557-60. doi: 10.1016/0091-3057(90)90289-t.
The effect of the calcium channel antagonists nifedipine, nimodipine, and diltiazem (10 mg/kg PO) was studied after single and repeated administration to rats. All the compounds administered repeatedly reduced significantly the duration of immobility in the forced swimming test. At the same time the locomotor activity of rats was reduced (nifedipine, nimodipine) or unchanged (diltiazem). All the calcium channel antagonists studied did not modify the behavior of normal or phenylephrine-stimulated rats in the open field test. Only nimodipine, given repeatedly, was able to antagonize the clonidine-induced behavioral inhibition in the latter test. The results indicate that, like antidepressants, calcium channel antagonists given repeatedly to rats reduce the immobility time in the forced swimming test, but do not change the responsiveness of alpha 1- and alpha 2-adrenoceptors to their agonists.
研究了钙通道拮抗剂硝苯地平、尼莫地平和地尔硫䓬（10毫克/千克，口服）对大鼠单次及重复给药后的影响。所有重复给药的化合物均显著缩短了强迫游泳试验中的不动时间。与此同时，大鼠的运动活性降低（硝苯地平、尼莫地平）或未改变（地尔硫䓬）。所研究的所有钙通道拮抗剂在旷场试验中均未改变正常或去氧肾上腺素刺激的大鼠的行为。仅重复给予的尼莫地平能够拮抗可乐定在后一试验中诱导的行为抑制。结果表明，与抗抑郁药一样，重复给予大鼠钙通道拮抗剂可缩短强迫游泳试验中的不动时间，但不会改变α1和α2肾上腺素能受体对其激动剂的反应性。
