Martín M I, del Val V L, Colado M I, Goicoechea C, Alfaro M J
Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense de Madrid, Spain.
Pharmacol Biochem Behav. 1996 Sep;55(1):93-8. doi: 10.1016/0091-3057(95)02289-9.
Evidence exists that calcium antagonists can have effects on neural function. The aim of this work is to analyze the effect of two dihydropyridines, nifedipine and nimodipine, administered for 11 days on the behavior and pain sensitivity of rats. Nociception was tested using the tail electric stimulation test, and behavior parameters using a holeboard. Our results show that chronic administration of nifedipine or nimodipine induces analgesia that can be evaluated by tail withdrawal. However, neither the vocalization nor the vocalization after discharge were modified, so the analgesia may be mediated by spinal mechanisms. Rats treated with nifedipine or nimodipine exhibited a dose-dependent tendency to avoid the center of the field without modification of other parameters, suggesting an increased emotivity in the rats. This conclusion is supported by the fact that anxiogenic or anxiolytic drugs modify the pattern of locomotion without significant changes in other parameters related with the motility. The results from this study suggest the view of a complex mechanism of action underlying nifedipine- and nimodipine-mediated behavioral effects.
有证据表明钙拮抗剂会对神经功能产生影响。本研究的目的是分析给予大鼠11天的两种二氢吡啶类药物硝苯地平和尼莫地平对其行为和疼痛敏感性的影响。使用尾部电刺激试验测试伤害感受，使用洞板测试行为参数。我们的结果表明，长期给予硝苯地平或尼莫地平会诱导镇痛作用，可通过尾部撤离来评估。然而，发声及放电后的发声均未改变，因此镇痛作用可能由脊髓机制介导。用硝苯地平或尼莫地平治疗的大鼠表现出剂量依赖性地倾向于避开场地中央，而其他参数未改变，这表明大鼠的情绪性增加。这一结论得到以下事实的支持：致焦虑或抗焦虑药物会改变运动模式，而与运动性相关的其他参数无显著变化。本研究结果提示硝苯地平和尼莫地平介导的行为效应背后存在复杂的作用机制。
