Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra 835215, India.
Int J Biol Macromol. 2011 Oct 1;49(3):305-10. doi: 10.1016/j.ijbiomac.2011.05.002. Epub 2011 May 11.
The objective of the study is to compare the different formulations prepared by using gum, grafted gum and hydrogel of katira as a carrier for colon-specific drug delivery using in vitro methods with and without enzymes. Katira gum is naturally occurring polysaccharides containing mainly l-rhamnose and d-galactose sugar unit and small percent of d-galactouronic acid. Compared to grafted gum and hydrogel, all proportions of katira gum protect the drug from being released completely in the physiological environment of the stomach and small intestine. In vitro release studies in enzymes (Pectinex Ultra SP-L having galactouronidase activity) have demonstrated the susceptibility of katira gum to the colonic bacterial enzyme (galactouronidase activity from Pectinex Ultra SP-L) with a consequent drug release. It illustrates that katira gum, a natural polysaccharide may be suitable as a carrier for colon targeting.
本研究的目的是比较使用瓜尔胶、接枝瓜尔胶和卡蒂拉水凝胶作为载体，通过体外方法（有酶和无酶）制备的不同制剂，用于结肠定位药物传递。卡蒂拉胶是一种天然存在的多糖，主要含有 l-鼠李糖和 d-半乳糖糖单元，以及少量的 d-半乳糖醛酸。与接枝胶和水凝胶相比，卡蒂拉胶的所有比例都能保护药物在胃和小肠的生理环境中完全释放。在酶（具有半乳糖醛酸酶活性的 Pectinex Ultra SP-L）的体外释放研究中，已经证明了卡蒂拉胶对结肠细菌酶（来自 Pectinex Ultra SP-L 的半乳糖醛酸酶活性）的敏感性，从而导致药物释放。这表明，卡蒂拉胶作为一种天然多糖，可能适合作为结肠靶向的载体。
