Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Ootacamund, India.
Int J Biol Macromol. 2011 Jun 1;48(5):773-8. doi: 10.1016/j.ijbiomac.2011.02.023. Epub 2011 Mar 15.
An oral buccoadhesive drug delivery system for Losartan potassium using a hydrophilic polysaccharide, isolated from Prunus amygdalaus (Badam gum), was developed and evaluated for its potential to overcome the drawbacks associated with the conventional drug therapy. The results of the study indicate that the isolated polysaccharide has good physicochemical and morphological characteristics and is suitable for use as a mucoadhesive sustain release polymer in pharmaceutical dosage forms, to alleviate the drawbacks of the conventional drug therapy of Losartan potassium.
开发了一种使用从杏仁（巴达姆胶）中分离得到的亲水性多糖的洛沙坦钾口腔颊黏膜给药系统，用于克服与传统药物治疗相关的缺点，并对其进行了评估。研究结果表明，分离得到的多糖具有良好的物理化学和形态特征，适合用作药物制剂中的粘膜粘附型缓释聚合物，以缓解洛沙坦钾传统药物治疗的缺点。
