Fonds de la Recherche Scientifique (FNRS), Laboratoire de Neurologie Expé rimentale, Université Libre de Bruxelles, Belgium.
Neurosci Lett. 2011 Jul 12;498(3):218-21. doi: 10.1016/j.neulet.2011.05.012. Epub 2011 May 11.
Our study aims at replicating our previous finding of an association between COMT rs4680 G/A polymorphism and early onset major depression (MD). We included 462 MD, 147 bipolar disorders (BD) subjects and 295 healthy controls. We could partially replicate previous findings. In particular, rs4680 GG+AG genotypes were more represented in the subgroup of early onset MD patients (p=0.04). Additionally, we observed an association between rs737865 alleles and early onset MD (p=0.04). Rs4680 genotype was associated with early onset BD as well (p=0.01). In conclusion, we partially replicated our previous findings confirming a possible influence of COMT variants in MD and BD, particularly in early onset subjects, though not with the same risk genotypes.
我们的研究旨在复制我们之前发现的 COMT rs4680 G/A 多态性与早发性重度抑郁症（MD）之间的关联。我们纳入了 462 名 MD 患者、147 名双相情感障碍（BD）患者和 295 名健康对照者。我们可以部分复制之前的发现。特别是，rs4680 GG+AG 基因型在早发性 MD 患者亚组中更为常见（p=0.04）。此外，我们还观察到 rs737865 等位基因与早发性 MD 之间存在关联（p=0.04）。rs4680 基因型也与早发性 BD 相关（p=0.01）。总之，我们部分复制了之前的发现，证实 COMT 变异可能对 MD 和 BD 有影响，特别是在早发性患者中，但风险基因型并不相同。
