Chair and Department of Clinical Neuropsychology, Nicolaus Copernicus University in Toruń, Collegium Medicum, Bydgoszcz 85-094, Poland.
Department of Endocrinology and Diabetology, Nicolaus Copernicus University in Toruń, Collegium Medicum, Bydgoszcz 85-094, Poland.
Int J Mol Sci. 2019 Apr 15;20(8):1847. doi: 10.3390/ijms20081847.
Studies indicate the heritable nature of affective temperament, which shows personality traits predisposing to the development of mental disorders. Dopaminergic gene polymorphisms such as , Val158Met, and have been linked to affective disorders in obesity. Due to possible correlation between the aforementioned polymorphisms and the affective temperament, the aim of our research was to investigate this connection in an obese population. The study enrolled 245 obese patients (178 females; 67 males). The affective temperament was assessed using the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego autoquestionnaire (TEMPS-A). Genetic polymorphisms of , Val158Met and were collected from peripheral blood sample and determined using a polymerase chain reaction (PCR). Only in COMT polymorphisms, the cyclothymic and irritable dimensions were significantly associated with Met/Val carriers ( = 0.04; = 0.01). Another interesting finding was the correlation between the affective temperament and age in men and women. We assume that dopamine transmission in heterozygotes of COMT may determine the role of the affective temperament in obese persons. Dopaminergic transmission modulated by COMT may be responsible for a greater temperament expression in obese individuals. To our knowledge, this is the first study describing the role of affective temperament in the obese population, but more research is needed in this regard.
研究表明情感气质具有遗传性，它显示出易患精神障碍的人格特质。多巴胺能基因多态性，如 Val158Met 和 ，与肥胖相关的情感障碍有关。由于上述多态性与情感气质之间可能存在相关性，我们的研究目的是在肥胖人群中研究这种联系。该研究纳入了 245 名肥胖患者（178 名女性；67 名男性）。使用孟菲斯、比萨、巴黎和圣地亚哥自动问卷的情感气质评估量表（TEMPS-A）评估情感气质。从外周血样中收集 Val158Met 和 基因多态性，并使用聚合酶链反应（PCR）确定。仅在 COMT 多态性中，环性和易怒维度与 Met/Val 携带者显著相关（ = 0.04； = 0.01）。另一个有趣的发现是情感气质与男女年龄之间的相关性。我们假设 COMT 杂合子中的多巴胺传递可能决定了情感气质在肥胖者中的作用。COMT 调节的多巴胺传递可能导致肥胖个体的气质表达更为明显。据我们所知，这是首次描述情感气质在肥胖人群中的作用的研究，但在这方面需要进一步研究。
