Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98104-2499, USA.
Gen Hosp Psychiatry. 2011 May-Jun;33(3):301.e9-11. doi: 10.1016/j.genhosppsych.2010.11.015. Epub 2011 Jan 8.
The increasing use of serotonergic agents, alone and in combination, across multiple disciplines, makes it likely that the prevalence of serotonin syndrome will rise. Caution should be used, especially in the elderly, to avoid unnecessary and potentially harmful polypharmacy. We describe a case of serotonin syndrome in a 79-year-old man taking mirtazapine, venlafaxine and quetiapine. As this case illustrates, serotonin syndrome can be caused by combinations of direct serotonin agonists (e.g., serotonergic antidepressants) and indirect serotonin agonists (e.g., atypical antipsychotics).
随着各种学科中单独或联合使用 5-羟色胺能药物的增加，5-羟色胺综合征的发生率可能会上升。因此，应谨慎使用，尤其是在老年人中，以避免不必要的、潜在有害的多药治疗。我们描述了 1 例同时服用米氮平、文拉法辛和喹硫平的 79 岁男性患者发生 5-羟色胺综合征的情况。正如本病例所示，5-羟色胺综合征可由直接 5-羟色胺激动剂（如 5-羟色胺能抗抑郁药）和间接 5-羟色胺激动剂（如非典型抗精神病药）联合引起。
