[Methods of statistical analysis in the complex evaluation of disorders of the blood levels of free amino acids in alcoholic abstinence syndrome].

A study was made of the formation of the pool of free amino acids in patients with the alcoholic abstinence syndrome (AAS) of varying gravity as well as in the course of detoxication therapy. On admission the patients demonstrated a marked negative relationship between the levels of alpha-aminobutyric acid, serine, cystine, glutamine and the gravity of the AAS. Both mild and grave patterns of the AAS are characterized by the rise of the content of alpha-aminobutyric acid, glycine, valine, phenylalanine, ammonia and by a dramatic decline of the glutamine level. The most informative parameters determined by linear discriminant analysis in the course of detoxication therapy include alpha-aminobutyric acid, lysine, alanine and glutamine. The adequacy of the use of factor analysis for the assessment of the efficacy of a complex of therapeutic measures is discussed.