[酒精中毒发展的神经生理学和病理形态学特征（实验研究）]

[Neurophysiologic and pathomorphologic characteristics of the development of alcoholism (experimental study)].

作者信息

Vorob'eva T M, Gordienko Zh P, Paĭkova L N

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1990;90(2):77-84.

Abstract

The neurophysiological and pathomorphological characteristics of experimental alcoholism formation were studied in chronic experiments with 30 rats using a method of recording the electrical activity of different brain structures, the reaction of self-stimulation of the ventrolateral hypothalamus, amygdala and reticular formation of the midbrain, ECG, arterial pressure, conditioned reflexes, review and specialized histochemical methods. Derangements of the electrical activity of the brain, conditioned reflexes, emotional and cardiovascular reactions shared by the limbicoreticular structures and neocortex were found to be dependent on the time of alcoholization. Comparison of the neurophysiological and pathomorphological alterations in the brain seen in experimental alcoholism points to the structural and functional disorders contributing to the failure of the compensatory and adaptation mechanisms.

摘要

采用记录不同脑结构电活动、腹外侧下丘脑、杏仁核及中脑网状结构的自我刺激反应、心电图、动脉血压、条件反射、常规及特殊组织化学方法，对30只大鼠进行慢性实验，研究实验性酒精中毒形成的神经生理学和病理形态学特征。发现边缘网状结构和新皮质共有的脑电活动、条件反射、情绪及心血管反应紊乱取决于酒精化时间。实验性酒精中毒时脑内神经生理学和病理形态学改变的比较表明，结构和功能紊乱导致代偿和适应机制失效。