Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
J Microbiol Immunol Infect. 2011 Dec;44(6):442-8. doi: 10.1016/j.jmii.2011.04.004. Epub 2011 May 23.
Cytomegalovirus (CMV) is a pathogen and can cause life-threatening infection in the patients with malignancies. This study was conducted to investigate the risk factors and outcomes of CMV viremia in patients with malignancies.
Data were collected with retrospective analysis from adults suffering from CMV viremia with underlying malignancies. A total of 107 patients were enrolled in a tertiary medical center in northern Taiwan from March 2008 to December 2009.
Among the 107 patients who suffered with CMV viremia with an overall mortality rate of 56.1% (60/107), 75 patients (70.1%) had solid organ malignancies and 32 (29.9%) had hematological malignancies. Mechanical ventilation (p=0.048), leukocytosis (p=0.004), and lack of appropriate early treatment (p=0.011) were independent predisposing factors associated with higher mortality rate.
CMV viremia predicts high mortality rate in cancer patients, especially in those with mechanical ventilation, leukocytosis, and lack of appropriate early treatment. Appropriate early antiviral therapy is recommended to improve outcomes.
巨细胞病毒（CMV）是一种病原体，可导致恶性肿瘤患者发生威胁生命的感染。本研究旨在探讨恶性肿瘤患者 CMV 血症的危险因素和结局。
采用回顾性分析方法，收集了台湾北部一家三级医疗中心 2008 年 3 月至 2009 年 12 月期间患有恶性肿瘤合并 CMV 血症的成人患者的数据。
在 107 例患有 CMV 血症的患者中，总死亡率为 56.1%（60/107），75 例（70.1%）患有实体器官恶性肿瘤，32 例（29.9%）患有血液恶性肿瘤。机械通气（p=0.048）、白细胞增多（p=0.004）和缺乏适当的早期治疗（p=0.011）是与更高死亡率相关的独立危险因素。
CMV 血症预示着癌症患者的高死亡率，尤其是那些需要机械通气、白细胞增多和缺乏适当早期治疗的患者。建议进行适当的早期抗病毒治疗以改善结局。
