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一名复发急性髓系白血病患者在全身化疗后，巨细胞病毒性结肠炎伪装成苹果核样病变。

Cytomegalovirus Colitis Masquerading as Apple-Core Lesion after Systemic Chemotherapy in a Patient with Relapsed Acute Myeloid Leukemia.

作者信息

An Jong, Brownell Jason, Barker Darrell, Stockinger Theresa, Brady Robert, Cebe Katherine, Baur Russell

机构信息

Department of Hematology and Oncology Service, San Antonio Military Medical Center, Fort Sam Houston, San Antonio, TX 78234, USA.

Department of Internal Medicine, San Antonio Military Medical Center, Fort Sam Houston, San Antonio, TX 78234, USA.

出版信息

Case Rep Oncol Med. 2018 Mar 20;2018:5683417. doi: 10.1155/2018/5683417. eCollection 2018.

DOI:10.1155/2018/5683417
PMID:29755802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5884229/
Abstract

We report the case of a 71-year-old male with relapsed acute myeloid leukemia who developed cytomegalovirus (CMV) colitis presenting as an apple-core lesion during induction chemotherapy. CMV infection occurs rarely during induction chemotherapy for acute myeloid leukemia. CMV infection is usually observed in patients with acquired immune deficiency syndrome (AIDS) and in those on immunosuppressive agents following bone marrow transplant. Although rare, CMV colitis should be considered in patients who are critically ill after systemic chemotherapy as it can cause significant morbidity and mortality.

摘要

我们报告了一例71岁复发急性髓系白血病男性患者，其在诱导化疗期间发生巨细胞病毒（CMV）结肠炎，表现为苹果核样病变。CMV感染在急性髓系白血病诱导化疗期间很少发生。CMV感染通常见于获得性免疫缺陷综合征（AIDS）患者以及骨髓移植后使用免疫抑制剂的患者。尽管罕见，但对于全身化疗后病情危重的患者应考虑CMV结肠炎，因为它可导致显著的发病率和死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cdb/5884229/717a2855c982/CRIONM2018-5683417.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cdb/5884229/ebd52db310d1/CRIONM2018-5683417.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cdb/5884229/0154945a1f34/CRIONM2018-5683417.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cdb/5884229/d3a3ca35ca42/CRIONM2018-5683417.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cdb/5884229/717a2855c982/CRIONM2018-5683417.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cdb/5884229/ebd52db310d1/CRIONM2018-5683417.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cdb/5884229/0154945a1f34/CRIONM2018-5683417.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cdb/5884229/d3a3ca35ca42/CRIONM2018-5683417.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cdb/5884229/717a2855c982/CRIONM2018-5683417.004.jpg

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本文引用的文献

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Clin Infect Dis. 2017 Jan 1;64(1):87-91. doi: 10.1093/cid/ciw668. Epub 2016 Sep 28.
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Cytomegalovirus colitis masquerading as rectal malignancy in an immunocompetent patient.在一名免疫功能正常的患者中，伪装成直肠恶性肿瘤的巨细胞病毒性结肠炎。
Indian J Pathol Microbiol. 2015 Jan-Mar;58(1):80-2. doi: 10.4103/0377-4929.151195.
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Risk factors for cytomegalovirus gastrointestinal diseases in adult patients with cancer.
成年癌症患者巨细胞病毒胃肠道疾病的危险因素。
Eur J Clin Microbiol Infect Dis. 2014 Oct;33(10):1847-53. doi: 10.1007/s10096-014-2107-x. Epub 2014 May 23.
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Detection of cytomegalovirus DNA in plasma as an adjunct diagnostic for gastrointestinal tract disease in kidney and liver transplant recipients.检测血浆中的巨细胞病毒 DNA 作为肾和肝移植受者胃肠道疾病的辅助诊断方法。
Clin Infect Dis. 2013 Dec;57(11):1550-9. doi: 10.1093/cid/cit521. Epub 2013 Aug 15.
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Cytomegalovirus colitis following azacitidine therapy.阿扎胞苷治疗后巨细胞病毒性结肠炎。
Can J Infect Dis Med Microbiol. 2011 Fall;22(3):e21-3. doi: 10.1155/2011/616725.
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