唾液链球菌通过抑制人肠道上皮细胞 NF-κB 通路发挥作用。
Inhibition of the NF-kappaB pathway in human intestinal epithelial cells by commensal Streptococcus salivarius.
机构信息
Commensal and Food Bacteria Group, INRA, UMR1319 Micalis, Domaine de Vilvert, F-78352 Jouy-en-Josas, France.
出版信息
Appl Environ Microbiol. 2011 Jul;77(13):4681-4. doi: 10.1128/AEM.03021-10. Epub 2011 May 20.
Abstract
Streptococcus salivarius exhibited an anti-inflammatory effect on intestinal epithelial cells (IECs) and monocytes. Strains were screened using a reporter clone, HT-29/kB-luc-E, induced by tumor necrosis factor alpha (TNF-α). Supernatant from each strain downregulated NF-κB activation. The two most efficient strains produced an active metabolite (<3 kDa) which was able to downregulate the secretion of the proinflammatory chemokine interleukin-8 (IL-8).
摘要
唾液链球菌对肠道上皮细胞（IECs）和单核细胞具有抗炎作用。使用肿瘤坏死因子α（TNF-α）诱导的报告克隆 HT-29/kB-luc-E 筛选菌株。来自每个菌株的上清液均下调 NF-κB 激活。两种最有效的菌株产生一种活性代谢物（<3 kDa），能够下调促炎趋化因子白细胞介素 8（IL-8）的分泌。
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