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唾液链球菌通过抑制人肠道上皮细胞 NF-κB 通路发挥作用。

Inhibition of the NF-kappaB pathway in human intestinal epithelial cells by commensal Streptococcus salivarius.

机构信息

Commensal and Food Bacteria Group, INRA, UMR1319 Micalis, Domaine de Vilvert, F-78352 Jouy-en-Josas, France.

出版信息

Appl Environ Microbiol. 2011 Jul;77(13):4681-4. doi: 10.1128/AEM.03021-10. Epub 2011 May 20.

DOI:10.1128/AEM.03021-10
PMID:21602373
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3127691/
Abstract

Streptococcus salivarius exhibited an anti-inflammatory effect on intestinal epithelial cells (IECs) and monocytes. Strains were screened using a reporter clone, HT-29/kB-luc-E, induced by tumor necrosis factor alpha (TNF-α). Supernatant from each strain downregulated NF-κB activation. The two most efficient strains produced an active metabolite (<3 kDa) which was able to downregulate the secretion of the proinflammatory chemokine interleukin-8 (IL-8).

摘要

唾液链球菌对肠道上皮细胞（IECs）和单核细胞具有抗炎作用。使用肿瘤坏死因子α（TNF-α）诱导的报告克隆 HT-29/kB-luc-E 筛选菌株。来自每个菌株的上清液均下调 NF-κB 激活。两种最有效的菌株产生一种活性代谢物（<3 kDa），能够下调促炎趋化因子白细胞介素 8（IL-8）的分泌。

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本文引用的文献

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PLoS One. 2010 Sep 30;5(9):e13092. doi: 10.1371/journal.pone.0013092.
2
Bifidobacterium lactis inhibits NF-kappaB in intestinal epithelial cells and prevents acute colitis and colitis-associated colon cancer in mice.乳双歧杆菌抑制肠道上皮细胞中的 NF-κB，预防小鼠急性结肠炎和结肠炎相关结肠癌。
Inflamm Bowel Dis. 2010 Sep;16(9):1514-25. doi: 10.1002/ibd.21262.
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Coordination of tolerogenic immune responses by the commensal microbiota.共生菌群对耐受性免疫反应的协调作用。
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Emergence of a cell wall protease in the Streptococcus thermophilus population.热链球菌种群中细胞壁蛋白酶的出现。
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