Department of Experimental Neuroendocrinology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland.
Pharmacol Rep. 2011;63(2):271-92. doi: 10.1016/s1734-1140(11)70497-2.
This article aims to summarize the current views of AED action and the promising new targets for the pharmacotherapy of epilepsy. In the first section of this paper, a neurobiological basis of epilepsy treatment and brief pharmacological characteristics of classical and new AEDs will be presented. In the second part, the results of experimental studies that have combined AEDs with similar or different mechanisms of action will be discussed.
本文旨在总结目前抗癫痫药物（AED）的作用观点以及癫痫治疗的有前景的新靶点。本文第一部分将介绍癫痫治疗的神经生物学基础以及经典和新型 AED 的简要药理学特征。第二部分将讨论联合具有相似或不同作用机制的 AED 进行的实验研究结果。
