MedInsight Research Institute, P.O. Box 386, Telz Stone, 90840, Israel.
Pharmacol Rep. 2011;63(2):337-47. doi: 10.1016/s1734-1140(11)70500-x.
Cepharanthine (CEP) is a naturally occurring alkaloid extracted from the plant Stephania cepharantha Hayata. It has been widely used in Japan for more than 40 years to treat a wide variety of acute and chronic diseases. CEP inhibits tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppresses cytokine production. It has also been shown to scavenge free radicals and to have a protective effect against some of the responses mediated by pro-inflammatory cytokines such as TNF-α, interleukin (IL)-1β and IL6. CEP has successfully been used to treat a diverse range of medical conditions, including radiation-induced leukopenia, idiopathic thrombocytopenic purpura, alopecia areata, alopecia pityrodes, venomous snakebites, xerostomia, sarcoidosis, refractory anemia and various cancer-related conditions. No safety issues have been observed with CEP, and side effects are very rarely reported.
石蒜裂碱（CEP）是一种从石蒜科植物石蒜中提取的天然生物碱。在日本，CEP 已被广泛应用于治疗各种急性和慢性疾病 40 多年。CEP 可抑制肿瘤坏死因子（TNF）-α 介导的 NFκB 刺激、质膜脂质过氧化和血小板聚集，并抑制细胞因子的产生。CEP 还能清除自由基，并对 TNF-α、白细胞介素（IL）-1β 和 IL6 等促炎细胞因子介导的某些反应具有保护作用。CEP 已成功用于治疗多种医疗病症，包括辐射引起的白细胞减少症、特发性血小板减少性紫癜、斑秃、脂溢性脱发、毒蛇咬伤、口干症、结节病、难治性贫血和各种与癌症相关的病症。CEP 未观察到安全性问题，且副作用非常罕见。
