Department of Ophthalmology, Interdisciplinary School of Medicine and Engineering, University of Yamanashi, Chuo Yamanashi, Japan.
J Glaucoma. 2012 Jun-Jul;21(5):296-301. doi: 10.1097/IJG.0b013e31821206b1.
To investigate longitudinal changes in anterior chamber depth (ACD) and anterior chamber angle (ACA) and the associated factors in patients with primary open-angle glaucoma using the scanning peripheral ACD analyzer.
The scanning peripheral ACD analyzer evaluated ACD by numeric grade (ACDG 1 to 12) and ACA twice in 2003 and 2008. The exclusion criteria were as follows: history of laser or incisional surgery, other ocular diseases that may affect visual field, visual acuity less than 20/30, and treatment with pilocarpine ophthalmic solution. Patients with pseudophakic eye were used as control.
One hundred fifty-seven patients with glaucoma and 26 patients with pseudophakic eye were subjected to the analysis. ACDG and ACA of patients with glaucoma were significantly decreased from 7.2±2.3 to 6.5±2.1 (P<0.001) and from 34.2±12.6 to 28.1±10.3 degrees (P<0.0001), respectively, whereas patients with cataract surgery showed no significant changes in ACDG and ACA. The change in ACD was greater at the peripheral region than at the central region. The decrease in ACDG was significantly associated with deep initial ACDG and wide ACA. Patients having shallow ACDG and narrow ACA showed more rapid deterioration of visual field than those having deep ACDG and wide ACA.
ACDG and ACA decreased with age, and initial ACDG and ACA were related to the progression of open-angle glaucoma.
使用扫描周边前房深度分析仪研究原发性开角型青光眼患者前房深度（ACD）和前房角（ACA）的纵向变化及其相关因素。
扫描周边前房深度分析仪以数值等级（ACDG 1 至 12）两次评估 2003 年和 2008 年的 ACD 和 ACA。排除标准如下：激光或切口手术史、可能影响视野的其他眼部疾病、视力低于 20/30、以及使用毛果芸香碱滴眼剂治疗。将无晶状体眼患者作为对照。
对 157 例青光眼患者和 26 例无晶状体眼患者进行了分析。青光眼患者的 ACDG 和 ACA 分别从 7.2±2.3 降至 6.5±2.1（P<0.001）和从 34.2±12.6 降至 28.1±10.3 度（P<0.0001），而白内障手术患者的 ACDG 和 ACA 无显著变化。周边区域的 ACD 变化大于中央区域。ACDG 的减少与初始 ACDG 较深和 ACA 较宽显著相关。ACDG 较浅和 ACA 较窄的患者视野恶化速度明显快于 ACDG 较深和 ACA 较宽的患者。
ACDG 和 ACA 随年龄增长而降低，初始 ACDG 和 ACA 与开角型青光眼的进展有关。
