Kouroupaki Anna I, Triantafyllopoulos George I, Pateras Evangelos, Karabatsas Costas H, Plakitsi Athina
Biomedical Sciences Department, Course of Optics and Optometry, University of West Attica, Athens, GRC.
Ophthalmology Department, 'Korgialenio-Benakio' Hellenic Red Cross General Hospital, Athens, GRC.
Cureus. 2024 Apr 21;16(4):e58703. doi: 10.7759/cureus.58703. eCollection 2024 Apr.
This prospective observational study investigates the impact of cataract surgery on anterior segment parameters in nonglaucomatous and primary open-angle glaucoma (POAG) eyes, utilizing anterior segment optical coherence tomography (AS-OCT). The study involved 42 Caucasian patients, divided into a control group and a POAG group. Comprehensive ophthalmic examinations were performed along with AS-OCT imaging and biometry preoperatively, as well as on one day, one week, and one month following cataract surgery. The results showed significant post-operative changes in anterior chamber depth (ACD) and angle width in both groups, suggesting that cataract surgery may influence the structural parameters associated with glaucoma risk and management. Specifically, a marked increase in ACD and improvement in angle-opening distances were observed, highlighting the potential of cataract extraction to alter intraocular fluid dynamics favorably. Despite these changes, the study noted an initial spike in increased intraocular pressure (IOP) in POAG patients immediately post-operative, which stabilized during follow-up. For the control group, IOP showed gradually reducing IOP values in the follow-up visits. The findings underscore the role of advanced imaging technologies in understanding glaucoma's pathophysiology and the potential benefits of cataract surgery in glaucoma patients. The study advocates for further research with a larger, more diverse patient population and extended follow-up to explore the long-term implications of cataract surgery on glaucoma dynamics, emphasizing the importance of personalized management and treatment strategies particularly for glaucoma patients.
这项前瞻性观察性研究利用眼前节光学相干断层扫描（AS-OCT），调查白内障手术对非青光眼和原发性开角型青光眼（POAG）患眼眼前节参数的影响。该研究纳入了42名白种人患者，分为对照组和POAG组。术前以及白内障手术后1天、1周和1个月进行了全面的眼科检查，包括AS-OCT成像和生物测量。结果显示，两组患者术后前房深度（ACD）和房角宽度均有显著变化，这表明白内障手术可能会影响与青光眼风险和治疗相关的结构参数。具体而言，观察到ACD显著增加，房角开放距离改善，突出了白内障摘除术有利地改变眼内流体动力学的潜力。尽管有这些变化，但该研究指出，POAG患者术后眼压（IOP）立即出现初始峰值，并在随访期间稳定下来。对于对照组，随访期间IOP值逐渐降低。这些发现强调了先进成像技术在理解青光眼病理生理学方面的作用，以及白内障手术对青光眼患者的潜在益处。该研究主张对更大、更多样化的患者群体进行进一步研究，并延长随访时间，以探索白内障手术对青光眼动态变化的长期影响，强调个性化管理和治疗策略对青光眼患者的重要性。
