Arcas-Carbonell María, Orduna-Hospital Elvira, Mechó-García María, Fernández-Espinosa Guisela, Sanchez-Cano Ana
Departamento de Física Aplicada, Universidad de Zaragoza, 50009 Zaragoza, Spain.
Instituto de Investigación Sanitaria de Aragón (IIS Aragón), 50009 Zaragoza, Spain.
J Imaging. 2025 Aug 1;11(8):257. doi: 10.3390/jimaging11080257.
This study describes and validates a novel method for assessing anterior crystalline lens curvature along vertical and horizontal meridians using radial measurements derived from Scheimpflug imaging. The aim was to evaluate whether pupil diameter (PD), anterior lens curvature, and anterior chamber depth (ACD) change during accommodation and whether these changes are age-dependent. A cross-sectional study was conducted on 104 right eyes from healthy participants aged 21-62 years. Sixteen radial images per eye were acquired using the Galilei Dual Scheimpflug Placido Disk Topographer under four accommodative demands (0, 1, 3, and 5 dioptres (D)). Custom software analysed lens curvature by calculating eccentricity in both meridians. Participants were analysed as a total group and by age subgroups. Accommodative amplitude and monocular accommodative facility were inversely correlated with age. Both PD and ACD significantly decreased with higher accommodative demands and age. Relative eccentricity decreased under accommodation, indicating increased lens curvature, especially in younger participants. Significant curvature changes were detected in the horizontal meridian only, although no statistically significant differences between meridians were found overall. The vertical meridian showed slightly higher eccentricity values, suggesting that it remained less curved. By enabling detailed, meridionally stratified in vivo assessment of anterior lens curvature, this novel method provides a valuable non-invasive approach for characterizing age-related biomechanical changes during accommodation. The resulting insights enhance our understanding of presbyopia progression, particularly regarding the spatial remodelling of the anterior lens surface.
本研究描述并验证了一种新方法，该方法利用从Scheimpflug成像获得的径向测量值来评估晶状体前表面在垂直和水平子午线上的曲率。目的是评估瞳孔直径（PD）、晶状体前曲率和前房深度（ACD）在调节过程中是否发生变化，以及这些变化是否与年龄有关。对104名年龄在21 - 62岁的健康参与者的右眼进行了横断面研究。使用伽利略双Scheimpflug普拉西多盘地形图仪在四种调节需求（0、1、3和5屈光度（D））下，每只眼睛采集16张径向图像。定制软件通过计算两个子午线上的偏心率来分析晶状体曲率。参与者被作为一个整体组和按年龄亚组进行分析。调节幅度和单眼调节能力与年龄呈负相关。随着调节需求增加和年龄增长，PD和ACD均显著减小。在调节状态下相对偏心率降低，表明晶状体曲率增加，尤其是在年轻参与者中。仅在水平子午线上检测到显著的曲率变化，尽管总体上各子午线之间未发现统计学上的显著差异。垂直子午线显示出略高的偏心率值，表明其曲率保持较小。通过能够对晶状体前曲率进行详细的、按子午线分层的体内评估，这种新方法为表征调节过程中与年龄相关的生物力学变化提供了一种有价值的非侵入性方法。由此获得的见解增强了我们对老花眼进展的理解，特别是关于晶状体前表面的空间重塑。
