Ljunggren O, Rosenquist J, Ransjö M, Lerner U H
Department of Oral Pathology, University of Umeå, Sweden.
Biosci Rep. 1990 Feb;10(1):121-6. doi: 10.1007/BF01116860.
The effect of bradykinin on prostaglandin E2 formation in cells from human trabecular bone has been studied. The cells responded to parathyroid hormone with enhanced cyclic AMP formation and were growing as cuboidal-shaped, osteoblast-like cells. In these isolated human osteoblast-like cells, bradykinin (1 mumol/l) caused a rapid (5 min) stimulation of prostaglandin E2 formation. This finding indicates that human osteoblasts are equipped with receptors for bradykinin linked to an increase in prostaglandin formation.
已经研究了缓激肽对人小梁骨细胞中前列腺素E2形成的影响。这些细胞对甲状旁腺激素有反应，环磷酸腺苷（cAMP）的形成增加，并且以立方形、成骨细胞样细胞的形式生长。在这些分离的人成骨细胞样细胞中，缓激肽（1微摩尔/升）可迅速（5分钟）刺激前列腺素E2的形成。这一发现表明人成骨细胞配备有与前列腺素形成增加相关的缓激肽受体。
