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Bradykinin B1 and B2 receptor agonists synergistically potentiate interleukin-1-induced prostaglandin biosynthesis in human gingival fibroblasts.

作者信息

Lerner U H, Modéer T

机构信息

Department of Oral Cell Biology, University of Umeå, Sweden.

出版信息

Inflammation. 1991 Dec;15(6):427-36. doi: 10.1007/BF00923340.

DOI:10.1007/BF00923340
PMID:1661707
Abstract

The interactions between bradykinin (BK) and interleukin-1 (IL-1) on prostaglandin formation in human gingival fibroblasts have been studied. IL-1 alpha and IL-1 beta stimulated prostaglandin E2 (PGE2) formation in the gingival fibroblasts with IL-1 beta being the most potent agonist. The effects of both IL-1 alpha and IL-1 beta on PGE2 biosynthesis was synergistically potentiated by BK, in a dose-related manner. The synergistic interaction between IL-1 beta and BK on PGE2 production was seen both with B1 (des-Arg9-BK) and B2 (BK, Lys-BK) BK receptor agonists. No synergistic interaction between BK and IL-1 beta was seen on arachidonic acid release. These data suggest that BK and IL-1 act in concert to enhance prostanoid formation in inflammatory lesions and that the level of interaction is distal to phospholipase activity.

摘要

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2
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本文引用的文献

1
Pharmacology of bradykinin and related kinins.缓激肽及相关激肽的药理学
Pharmacol Rev. 1980 Mar;32(1):1-46.
2
The effect of the phenytoin metabolite p-HPPH on proliferation of gingival fibroblasts in vitro.
Acta Odontol Scand. 1982;40(5):353-7. doi: 10.3109/00016358209024080.
3
An interleukin 1 like factor stimulates bone resorption in vitro.一种白细胞介素-1样因子在体外刺激骨吸收。
Nature. 1983;306(5941):378-80. doi: 10.1038/306378a0.
Toll 样受体 2 的激活诱导人牙龈成纤维细胞和小鼠牙龈中的 B 和 B 缓激肽受体。
Sci Rep. 2019 Feb 27;9(1):2973. doi: 10.1038/s41598-018-37777-z.
4
Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation.通过抗ADAM17抗体D1（A12）靶向ADAM17的脱落酶活性，可通过阻断缓激肽诱导的HERs反式激活来抑制头颈部鳞状细胞癌细胞的增殖和迁移。
Int J Biol Sci. 2014 Jun 21;10(7):702-14. doi: 10.7150/ijbs.9326. eCollection 2014.
5
IL-4 and IL-13 inhibit IL-1β and TNF-α induced kinin B1 and B2 receptors through a STAT6-dependent mechanism.白细胞介素-4和白细胞介素-13通过一种依赖信号转导和转录激活因子6（STAT6）的机制抑制白细胞介素-1β和肿瘤坏死因子-α诱导的激肽B1和B2受体。
Br J Pharmacol. 2013 May;169(2):400-12. doi: 10.1111/bph.12116.
6
Endotoxin sensitization to kinin B(1) receptor agonist in a non-human primate model: haemodynamic and pro-inflammatory effects.非人灵长类动物模型中内毒素对缓激肽B(1)受体激动剂的致敏作用：血流动力学和促炎效应
Br J Pharmacol. 2001 Jan;132(1):327-35. doi: 10.1038/sj.bjp.0703748.
7
Differential regulation of bradykinin receptor density, intracellular Ca2+, and prostanoid release in skin and foreskin fibroblasts. Effects of cell density and interleukin-1alpha.皮肤和包皮成纤维细胞中缓激肽受体密度、细胞内钙离子及类前列腺素释放的差异调节。细胞密度和白细胞介素-1α的影响。
Br J Pharmacol. 1999 May;127(2):583-9. doi: 10.1038/sj.bjp.0702578.
8
Novel pharmacological strategies for analgesia.新型镇痛药理学策略。
Ann Rheum Dis. 1996 Oct;55(10):715-22. doi: 10.1136/ard.55.10.715.
9
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10
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Br J Pharmacol. 1996 Jul;118(6):1469-76. doi: 10.1111/j.1476-5381.1996.tb15562.x.
4
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J Clin Invest. 1984 Dec;74(6):2249-53. doi: 10.1172/JCI111651.
5
Competitive antagonists of bradykinin.缓激肽的竞争性拮抗剂。
Peptides. 1985 Mar-Apr;6(2):161-4. doi: 10.1016/0196-9781(85)90033-6.
6
Bradykinin, a new potential mediator of inflammation-induced bone resorption. Studies of the effects on mouse calvarial bones and articular cartilage in vitro.
Arthritis Rheum. 1987 May;30(5):530-40. doi: 10.1002/art.1780300507.
7
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Annu Rev Immunol. 1988;6:49-83. doi: 10.1146/annurev.iy.06.040188.000405.
8
Regulation of fibroblast cyclooxygenase synthesis by interleukin-1.白细胞介素-1对成纤维细胞环氧化酶合成的调节
J Biol Chem. 1988 Feb 25;263(6):3022-8.
9
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J Oral Pathol Med. 1989 Apr;18(4):246-50. doi: 10.1111/j.1600-0714.1989.tb00772.x.
10
Bradykinin stimulates production of prostaglandin E2 and prostacyclin in murine osteoblasts.
Bone Miner. 1989 Jan;5(2):139-54. doi: 10.1016/0169-6009(89)90092-5.