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呼吸道合胞病毒感染引发青春期前女童Graves病(此前未确诊)的甲状腺危象。

Respiratory syncytial virus infection as a precipitant of thyroid storm in a previously undiagnosed case of graves' disease in a prepubertal girl.

作者信息

Aslan Ivy R, Baca Elizabeth A, Charlton R William, Rosenthal Stephen M

机构信息

Division of Endocrinology, Department of Pediatrics, University of California, San Francisco, CA 94143, USA.

出版信息

Int J Pediatr Endocrinol. 2011;2011(1):138903. doi: 10.1155/2011/138903. Epub 2011 Mar 22.

Abstract

Graves' disease is less common in prepubertal than pubertal children, and initial presentation with thyroid storm is rare. We report an 11-year-old prepubertal Hispanic girl who presented with a one-day history of respiratory distress, fever, and dysphagia. She had exophthalmos, a diffuse bilateral goiter and was agitated, tachycardic, and hypertensive. Nasal swab was positive for respiratory syncytial virus (RSV). She was diagnosed with thyroid storm and admitted to the pediatric intensive care unit. While infection is a known precipitant of thyroid storm and RSV is a common pediatric infection, to the best of our knowledge, this is the first reported case of RSV infection apparently precipitating thyroid storm in a prepubertal child.

摘要

格雷夫斯病在青春期前儿童中比青春期儿童少见,且以甲状腺风暴为首发表现的情况罕见。我们报告一名11岁青春期前西班牙裔女孩,她有1天的呼吸窘迫、发热和吞咽困难病史。她有眼球突出、双侧弥漫性甲状腺肿,且烦躁不安、心动过速和高血压。鼻拭子呼吸道合胞病毒(RSV)检测呈阳性。她被诊断为甲状腺风暴并入住儿科重症监护病房。虽然感染是甲状腺风暴已知的诱发因素,且RSV是常见的儿科感染,但据我们所知,这是首例报告的RSV感染明显诱发青春期前儿童甲状腺风暴的病例。

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