Vintiner G M, Pearce E I
Dental Research Unit, MRC of New Zealand, Wellington.
Caries Res. 1990;24(2):101-6. doi: 10.1159/000261248.
The effect of purified monofluorophosphate (MFP) on the formation of hydroxyapatite (HA) in supersaturated calcium phosphate solutions was determined. In solutions initially at pH 7.4 and seeded with HA crystals, MFP was hydrolysed to a small extent, releasing F-. Once the crystal growth-enhancing property of this F- was compensated for, 4 mmol/l MFP could be shown to inhibit precipitation by 40%. Without compensation for F-, MFP appeared to inhibit precipitation by only 18%. This inhibition was weaker than that caused by pyrophosphate or ethane-1-hydroxy-1,1-diphosphonic acid. Because MFP is hydrolysed on apatite surfaces to F-, use of sodium MFP as an anticaries agent is unlikely to cause significant inhibition of enamel remineralization.
测定了纯化的单氟磷酸酯（MFP）对过饱和磷酸钙溶液中羟基磷灰石（HA）形成的影响。在初始pH为7.4且接种了HA晶体的溶液中，MFP会发生少量水解，释放出F-。一旦这种F-促进晶体生长的特性得到补偿，4 mmol/L的MFP可使沉淀抑制40%。若未对F-进行补偿，MFP似乎仅能抑制18%的沉淀。这种抑制作用比焦磷酸盐或乙烷-1-羟基-1,1-二膦酸引起的抑制作用弱。由于MFP在磷灰石表面水解为F-，因此使用MFP钠作为防龋剂不太可能对牙釉质再矿化产生显著抑制作用。
