Fox J L, Iyer B V, Higuchi W I, Hefferren J J
J Pharm Sci. 1983 Nov;72(11):1252-5. doi: 10.1002/jps.2600721104.
The effects of changing the ion activity product of the remineralization solution at pH 4.5 (pKFAP 108-118) on the remineralization behavior of demineralized bovine tooth enamel and hydroxyapatite pellets have been studied. Solutions containing calcium-4.5, phosphate, and fluoride in acetate buffers were used. The 45Ca/F molar ratios indicated the formation of fluoridated hydroxyapatite in the enamel or the pellet when the pKFAP values for remineralizing solutions were less than 112. When the pKFAP values were greater than 112, the 45Ca/F ratios were found to be much less than 5. Also, when the pKFAP values were large (greater than 112), the remineralization patterns based on the fluoride distribution in the tooth (or pellet) were found to be different than when the pKFAP values were small (less than 112). The hypothesis that a pKFAP value of 112 is the demarcation between remineralization only and simultaneous dissolution-remineralization has been proposed based on these results.
研究了在pH 4.5（pKFAP 108 - 118）条件下改变再矿化溶液的离子活度积对脱矿牛牙釉质和羟基磷灰石颗粒再矿化行为的影响。使用了在醋酸盐缓冲液中含有钙 - 4.5、磷酸盐和氟化物的溶液。当再矿化溶液的pKFAP值小于112时，45Ca/F摩尔比表明在牙釉质或颗粒中形成了含氟羟基磷灰石。当pKFAP值大于112时，发现45Ca/F比远小于5。此外，当pKFAP值较大（大于112）时，基于牙齿（或颗粒）中氟分布的再矿化模式与pKFAP值较小时（小于112）不同。基于这些结果，有人提出pKFAP值为112是仅再矿化与同时溶解 - 再矿化之间的分界线这一假设。
