1,6 - 二磷酸果糖作为大鼠体内外的抗酒精剂
Fructose-1,6-diphosphate as an in vitro and in vivo anti-alcohol agent in the rat.
作者信息
Galzigna L, Bianchi M, Rizzoli V, Scuri R, Giannetti P, Paesano A
机构信息
Department of Biological Chemistry, University of Padova, Italy.
出版信息
Cell Biochem Funct. 1990 Jan;8(1):39-47. doi: 10.1002/cbf.290080107.
Fructose-1, 6-diphosphate (FDP) decreases the effect of ethanol on Ca++ entry and inhibits the ethanol-stimulated phosphate efflux in rat heart slices. FDP also inhibits the ethanol-stimulated [36Cl-]-uptake by rat brain microvesicles and affects the isolated GABA-receptor in a way opposite to that of ethanol. The in vivo effects of FDP include a dose-dependent decrease in ethanol-induced gastric ulcers and a decrease in the serum transaminase levels raised by chronic ethanol administration. Other central actions of ethanol such as diuresis, narcosis, dependence and withdrawal symptoms are also counteracted by FDP.
果糖-1,6-二磷酸（FDP）可降低乙醇对钙离子内流的影响，并抑制大鼠心脏切片中乙醇刺激的磷酸盐外流。FDP还可抑制大鼠脑微囊泡对乙醇刺激的[36Cl-]摄取，并以与乙醇相反的方式影响分离的γ-氨基丁酸（GABA）受体。FDP的体内作用包括剂量依赖性地减少乙醇诱导的胃溃疡，以及降低慢性乙醇给药引起的血清转氨酶水平。乙醇的其他中枢作用，如利尿、麻醉、依赖性和戒断症状，也可被FDP抵消。
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