Kaye Alan D, Sabartinelli Alecia L, Kaye Adam M, Holtzman Alan M, Samm Paul L
Ochsner J. 2010 Fall;10(3):205-9.
The use of phenylephrine has been well described as a potential cause of morbidity and mortality. A thorough literature review of phenylephrine use is presented in this article. The use of ketamine and epinephrine with phenylephrine can precipitate an even more potentially lethal and catastrophic syndrome. We present the case of a 21-year-old man with Hodgkin's lymphoma and lupus who experienced an abrupt hypertensive crisis followed by pulseless electrical activity and cardiogenic shock after application of 2.5% phenylephrine-soaked nasal pledgets prior to excision of a large nasopharyngeal tumor. This case report adds to the current literature on the potential dangers of phenylephrine in clinical practice and describes a case of reversible severe left ventricular dysfunction in the setting of excessive pharmacologically induced sympathetic stimulation.
去氧肾上腺素的使用已被充分描述为发病和死亡的潜在原因。本文对去氧肾上腺素的使用进行了全面的文献综述。氯胺酮和肾上腺素与去氧肾上腺素联合使用可能会引发一种更具潜在致命性和灾难性的综合征。我们报告了一例21岁患有霍奇金淋巴瘤和狼疮的男性患者，在切除一个大的鼻咽肿瘤之前，使用2.5%去氧肾上腺素浸泡的鼻棉塞后，突然出现高血压危象，随后出现无脉电活动和心源性休克。本病例报告补充了当前关于去氧肾上腺素在临床实践中潜在危险的文献，并描述了一例在药理学诱导的过度交感神经刺激情况下可逆性严重左心室功能障碍的病例。
