Zetzmann Christopher P, Swamy O Rama, Loss George E, Bohorquez Humberto, Cohen Ari J
Transplantation Research Laboratory, Ochsner Clinic Foundation, New Orleans, LA.
Ochsner J. 2010 Winter;10(4):250-5.
Hepatic ischemia/reperfusion (I/R) injury has a significant influence on the outcome of liver transplants. Inhibiting certain enzymatic reactions that occur during I/R injury may have a protective effect on the liver during transplantation. After reviewing the biochemical pathways involved in hepatic I/R injury, we describe a pharmacologic line of defense against this injury by means of the enzyme tissue inhibitor of metalloproteinase 3 (TIMP-3). Current results suggest that TIMP-3 will play a clinically relevant role in improving outcomes of liver transplants by reducing I/R injury to the donor liver.
肝缺血/再灌注（I/R）损伤对肝移植的结果有重大影响。抑制I/R损伤期间发生的某些酶促反应可能在移植过程中对肝脏起到保护作用。在回顾了肝I/R损伤所涉及的生化途径后，我们描述了一种通过金属蛋白酶组织抑制剂3（TIMP-3）来对抗这种损伤的药理学防御方法。目前的结果表明，TIMP-3将通过减少对供体肝脏的I/R损伤，在改善肝移植结果方面发挥临床相关作用。
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