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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Gordon R D, Tunny T J, Klemm S A, Finn W L, Hawkins P J, Hunyor S J, Norris J J

Endocrine-Hypertension Research Unit, University Department of Medicine, Brisbane, Queensland, Australia.

Clin Exp Pharmacol Physiol. 1990 Mar;17(3):185-9. doi: 10.1111/j.1440-1681.1990.tb01303.x.

A 17 year old female presented with severe hypertension, hypokalaemia and elevated levels of plasma renin activity due to a renin-secreting tumour. 2. Renin was responsive to posture, low sodium diet, saline infusion and frusemide, but relatively unresponsive to raising or lowering circulating levels of angiotensin II. 3. Renal venous renin levels lateralized to the side of the tumour with good contralateral suppression when measured with control of posture and avoidance of prior stimulation, with and without angiotensin converting enzyme inhibition. 4. Levels of atrial natriuretic peptide were elevated and responsive to posture, saline infusion and angiotensin infusion. 5. The tumour was evident on computerized tomography, but not on intravenous pyelography or renal angiography. 6. Responsiveness of renin secretion to normal stimuli in reninoma may make diagnosis difficult, and renal vein sampling under controlled conditions is necessary.

一名17岁女性因分泌肾素的肿瘤出现严重高血压、低钾血症及血浆肾素活性升高。2. 肾素对体位、低钠饮食、盐水输注和速尿有反应，但对升高或降低循环中血管紧张素II水平相对无反应。3. 在控制体位并避免先前刺激的情况下，无论有无血管紧张素转换酶抑制，肾静脉肾素水平在肿瘤侧呈单侧化，对侧有良好抑制。4. 心房利钠肽水平升高，对体位、盐水输注和血管紧张素输注有反应。5. 肿瘤在计算机断层扫描中可见，但在静脉肾盂造影或肾血管造影中未见。6. 肾素瘤中肾素分泌对正常刺激的反应性可能使诊断困难，因此在受控条件下进行肾静脉采样是必要的。

Gordon R D, Tunny T J, Klemm S A, Finn W L, Hawkins P J, Hunyor S J, Norris J J

Endocrine-Hypertension Research Unit, University Department of Medicine, Brisbane, Queensland, Australia.

Clin Exp Pharmacol Physiol. 1990 Mar;17(3):185-9. doi: 10.1111/j.1440-1681.1990.tb01303.x.

A 17 year old female presented with severe hypertension, hypokalaemia and elevated levels of plasma renin activity due to a renin-secreting tumour. 2. Renin was responsive to posture, low sodium diet, saline infusion and frusemide, but relatively unresponsive to raising or lowering circulating levels of angiotensin II. 3. Renal venous renin levels lateralized to the side of the tumour with good contralateral suppression when measured with control of posture and avoidance of prior stimulation, with and without angiotensin converting enzyme inhibition. 4. Levels of atrial natriuretic peptide were elevated and responsive to posture, saline infusion and angiotensin infusion. 5. The tumour was evident on computerized tomography, but not on intravenous pyelography or renal angiography. 6. Responsiveness of renin secretion to normal stimuli in reninoma may make diagnosis difficult, and renal vein sampling under controlled conditions is necessary.

一名17岁女性因分泌肾素的肿瘤出现严重高血压、低钾血症及血浆肾素活性升高。2. 肾素对体位、低钠饮食、盐水输注和速尿有反应，但对升高或降低循环中血管紧张素II水平相对无反应。3. 在控制体位并避免先前刺激的情况下，无论有无血管紧张素转换酶抑制，肾静脉肾素水平在肿瘤侧呈单侧化，对侧有良好抑制。4. 心房利钠肽水平升高，对体位、盐水输注和血管紧张素输注有反应。5. 肿瘤在计算机断层扫描中可见，但在静脉肾盂造影或肾血管造影中未见。6. 肾素瘤中肾素分泌对正常刺激的反应性可能使诊断困难，因此在受控条件下进行肾静脉采样是必要的。