Farrell Erin, Sacks Joel G
Department of Ophthalmology, Ochsner Clinic Foundation, New Orleans, LA.
Ochsner J. 2008 Fall;8(3):140-5.
Optic neuropathy has been reported in association with the use of tumor necrosis factor-alpha antagonists such as etanercept, infliximab, and adalimumab. This is a report of a patient who began experiencing decreased vision approximately 1 month after starting infliximab therapy for rheumatoid arthritis. Visual field testing showed bitemporal hemianopic scotomas, indicating involvement of the nerve fibers in the optic chiasm. The infliximab was discontinued, and the patient experienced substantial improvement in her visual acuity and visual field.
据报道，使用肿瘤坏死因子-α拮抗剂（如依那西普、英夫利昔单抗和阿达木单抗）会引发视神经病变。本文报告了一名类风湿关节炎患者，在开始使用英夫利昔单抗治疗约1个月后出现视力下降。视野检查显示双颞侧偏盲性暗点，提示视交叉神经纤维受累。停用英夫利昔单抗后，患者的视力和视野有显著改善。
