Chicken sarcoma to human cancers: a lesson in molecular therapeutics.
作者信息
Prakash Om, Bardot Stephen F, Cole John T
出版信息
Ochsner J. 2007 Summer;7(2):61-4.
Abstract
摘要
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Chicken sarcoma to human cancers: a lesson in molecular therapeutics.鸡肉瘤与人类癌症：分子治疗的一课
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Dasatinib.达沙替尼
Drugs Today (Barc). 2007 Jan;43(1):5-12. doi: 10.1358/dot.2007.43.1.1050791.
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Lyn is an important component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD.Lyn是FLT3/ITD特异性信号转导通路的重要组成部分，可成为治疗伴有FLT3/ITD的急性髓系白血病的治疗靶点。
Leukemia. 2007 Mar;21(3):403-10. doi: 10.1038/sj.leu.2404547. Epub 2007 Jan 18.
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Src tyrosine kinase as a chemotherapeutic target: is there a clinical case?Src酪氨酸激酶作为一种化疗靶点：是否存在临床病例？
Anticancer Drugs. 2006 Feb;17(2):123-31. doi: 10.1097/00001813-200602000-00002.
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Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells.Src家族激酶抑制剂达沙替尼（BMS-354825）对人前列腺癌细胞的作用。
Cancer Res. 2005 Oct 15;65(20):9185-9. doi: 10.1158/0008-5472.CAN-05-1731.
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NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia.NS-187是一种强效且具有选择性的双Bcr-Abl/Lyn酪氨酸激酶抑制剂，是一种用于治疗对伊马替尼耐药的白血病的新型药物。
Blood. 2005 Dec 1;106(12):3948-54. doi: 10.1182/blood-2005-06-2209. Epub 2005 Aug 16.
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Distinct and opposite roles for SH2 and SH3 domains of v-src in embryo survival and hemangiosarcoma formation.v-src的SH2和SH3结构域在胚胎存活和血管肉瘤形成中具有截然不同且相反的作用。
Clin Exp Metastasis. 2005;22(2):167-75. doi: 10.1007/s10585-005-6930-4.
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Lyn kinase activity is the predominant cellular SRC kinase activity in glioblastoma tumor cells.Lyn激酶活性是胶质母细胞瘤肿瘤细胞中主要的细胞SRC激酶活性。
Cancer Res. 2005 Jul 1;65(13):5535-43. doi: 10.1158/0008-5472.CAN-04-3688.
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Src family tyrosine kinases are activated by Flt3 and are involved in the proliferative effects of leukemia-associated Flt3 mutations.Src家族酪氨酸激酶被Flt3激活，并参与白血病相关Flt3突变的增殖效应。
Exp Hematol. 2005 Apr;33(4):469-79. doi: 10.1016/j.exphem.2005.01.004.
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Activation of Src kinase Lyn by the Kaposi sarcoma-associated herpesvirus K1 protein: implications for lymphomagenesis.卡波西肉瘤相关疱疹病毒K1蛋白对Src激酶Lyn的激活：对淋巴瘤发生的影响
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Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis.慢性淋巴细胞白血病B细胞含有异常的Lyn酪氨酸激酶，这可能是导致凋亡缺陷的一个因素。
J Clin Invest. 2005 Feb;115(2):369-78. doi: 10.1172/JCI22094.
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