Lima Valmir Jose de, Andrade Claudia Roberta de, Ruschi Gustavo Enrico, Sass Nelson
Obstetrics Department, Universidade Federal de São Paulo, Brazil.
Sao Paulo Med J. 2011 Mar;129(2):73-6. doi: 10.1590/s1516-31802011000200004.
Pre-eclampsia is a disorder that occurs only during pregnancy. Postpartum changes relating to lipid metabolism may contribute towards the endothelial lesions observed in preeclampsia. Thus, the aim of the present study was to evaluate the lipid profile among patients who present preeclampsia and correlate these parameters with 24-hour proteinuria.
Cross-sectional analytical study including 77 pregnant patients seen at Hospital Dório Silva.
This study involved 42 women with preeclampsia and 35 healthy pregnant women in the third trimester of pregnancy as controls. Blood samples were obtained from all the patients, and the serum levels of triglycerides, total cholesterol, low-density lipoproteins (LDL), high-density lipoproteins (HDL) and very low density lipoproteins (VLDL) were determined. Cases and controls were matched for maternal age, gestational week and body mass index.
The VLDL and triglyceride values from the women with preeclampsia were significantly higher than those of the healthy women. There was a positive correlation between increased proteinuria and higher VLDL and triglyceride levels in patients with preeclampsia.
Among the patients with preeclampsia, higher VLDL and triglyceride levels were positively correlated with proteinuria. These observations indicate that the pregnant women who presented elevated lipid levels were more susceptible to cardiovascular disorders and, consequently, pre-eclampsia.
子痫前期是一种仅在孕期发生的疾病。与脂质代谢相关的产后变化可能导致子痫前期中观察到的内皮损伤。因此，本研究的目的是评估子痫前期患者的血脂谱，并将这些参数与24小时蛋白尿相关联。
横断面分析研究，纳入了在多里奥·席尔瓦医院就诊的77名孕妇。
本研究纳入42名单纯子痫前期女性患者和35名孕晚期健康孕妇作为对照。采集所有患者的血样，测定血清甘油三酯、总胆固醇、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）和极低密度脂蛋白（VLDL）水平。病例组和对照组在产妇年龄、孕周和体重指数方面进行匹配。
子痫前期女性患者的VLDL和甘油三酯值显著高于健康女性。子痫前期患者蛋白尿增加与较高的VLDL和甘油三酯水平之间存在正相关。
在子痫前期患者中，较高的VLDL和甘油三酯水平与蛋白尿呈正相关。这些观察结果表明，血脂水平升高的孕妇更容易患心血管疾病，进而易患子痫前期。
